Influence of ten-day head-down bedrest on human carotid baroreceptor-cardiac reflex function.

Influence of ten-day head-down bedrest on human carotid baroreceptor-cardiac reflex function. Research Abstract Details 

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Influence of ten-day head-down bedrest on human carotid baroreceptor-cardiac reflex function. Abstract Text:

D L Eckberg,J M Fritsch,

We studied the effects of simulated microgravity on baroreceptor-cardiac reflex mechanisms, with complex pressure changes delivered to neck chambers worn by six healthy young men, before, during (days 1, 3, 6, and 10), and after ten days' 6 degrees head-down bedrest. During held expiration, a computer-driven bellows increased neck pressure to 40 mmHg for about 4 s, and then decreased pressure to -65, by 15 mmHg R-wave triggered decrements. We plotted R-R intervals as functions of carotid distending pressures (systolic less neck chamber pressures). Each experimental session comprised seven stimulus sequences delivered over about 15 min and averaged. Comparisons between results before bedrest and on the tenth day of bedrest showed that average baseline R-R intervals increased from 933 +/- (SEM) 24 to 1077 +/- 35 msec (P less than 0.05, Wilcoxon signed rank test); maximum slopes (R-R interval/carotid distending pressure) decreased from 4.5 +/- 0.4 to 3.6 +/- 0.7 msec/mmHg (P = 0.11); R-R interval response ranges decreased from 263 +/- 31 to 182 +/- 18 msec (P = 0.03); and operational points (positions of R-R intervals at resting pressures on the stimulus-response relation) remained constant. Our results suggest that head-down bedrest progressively impairs baroreceptor-cardiac reflex responses in healthy human subjects.

Influence of ten-day head-down bedrest on human carotid baroreceptor-cardiac reflex function. Publishing Authors By Initials

DL Eckberg,JM Fritsch,

For similar natural sciences: physics: gravitation: gravity, altered: hypogravity: weightlessness research abstracts see: natural sciences: physics: gravitation: gravity, altered: hypogravity: weightlessness research

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Influence of ten-day head-down bedrest on human carotid baroreceptor-cardiac reflex function. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Acta physiologica Scandinavica. Supplementum

VOLUME: 604

Page Numbers: 69-76

Journal Abbreviation:

ISSN: 0302-2994

DAY: 20

MONTH: 02

YEAR: 1992

Influence of ten-day head-down bedrest on human carotid baroreceptor-cardiac reflex function. Information

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LANGUAGE: eng

NlmUniqueID: 376307

Influence of ten-day head-down bedrest on human carotid baroreceptor-cardiac reflex function. Keywords Mesh Terms:

KEYWORDS: Weightlessness

MESH TERMS: physiology

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Grant and Affiliation Information for Influence of ten-day head-down bedrest on human carotid baroreceptor-cardiac reflex function.

AFFILIATION: Hunter Homes McGuire VA Med Ctr, Richmond, VA

Country: ENGLAND

AGENCY: United States NHLBI

GRANT: HL-22296

ACRONYM: HL

MEDLINETA: Acta Physiol Scand Suppl

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