[Influence of tangential excision within 24 postburn hours on the local wound inflammatory response in patients with deep partial thickness burn]

[Influence of tangential excision within 24 postburn hours on the local wound inflammatory response in patients with deep partial thickness burn] Research Abstract Details 

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[Influence of tangential excision within 24 postburn hours on the local wound inflammatory response in patients with deep partial thickness burn] Abstract Text:

Shu-Liang Lu,Zhen-Jiang Liao,Jun Xiang,Zhi-Yong Wang,Li-Ying Yang,Shu-Wen Jin,Ji-Xiang Shi,

OBJECTIVE: To investigate the influence of early tangential excision within 24 postburn hours on local wound inflammatory response and tissue injury in patients with deep partial thickness burn. METHODS: Twelve patients with deep partial thickness burn were enrolled in the study. Tangential excision was performed within 24 postburn hours. The same wound of a patient was divided into three areas for harvesting tissue samples, i.e. pre-operation, post-operation and non-operation areas. For each patient, the biopsies from the pre-operation area were harvested before tangential excision, while those from post-operation and non-operation areas were harvested during 5 to 7 postburn days (PBDs). The contents of IL-8, MPO and MDA in wound tissue were determined by tissue culture and chemical colorimetry, respectively. HE and Mason's staining were employed to assess the degree of necrosis of the wound tissue. RESULTS: The IL-8, MPO and MDA contents in the local wound tissue after tangential excision were 6.83 +/- 1.85 microg/L, 4.07 +/- 0.87 U/g, and 8.94 +/- 5.66 micromol/g, respectively, which were significantly lower than those from non-operation area (P < 0.01). The inflammatory response in the non-operative wound area was distinct with expansion of necrotic tissue area. In contrast, the local inflammatory response of the wound after tangential excision was ameliorated without the enlargement of necrotic tissue area. CONCLUSION: Tangential excision within 24 postburn hours could be beneficial in ameliorating local inflammatory response, and in preventing progressive deepening of the burn wounds, thus it could accelerate wound healing in patients with deep partial thickness burn.

[Influence of tangential excision within 24 postburn hours on the local wound inflammatory response in patients with deep partial thickness burn] Publishing Authors By Initials

SL Lu,ZJ Liao,J Xiang,ZY Wang,LY Yang,SW Jin,JX Shi,

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[Influence of tangential excision within 24 postburn hours on the local wound inflammatory response in patients with deep partial thickness burn] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang za

VOLUME: 21

Page Numbers: 24-6

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ISSN: 1009-2587

DAY: 30

MONTH: Feb

YEAR: 2005

[Influence of tangential excision within 24 postburn hours on the local wound inflammatory response in patients with deep partial thickness burn] Information

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LANGUAGE: chi

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AFFILIATION: Department of Burns, Ruijin Hospital of Shanghai Second Medical University. Shanghai 200025, P.R. China.

Country: China

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MEDLINETA: Zhonghua Shao Shang Za Zhi

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