Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers.

Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. Research Abstract Details 

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Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. Abstract Text:

Maternal renal hemodynamic adaptation to human pregnancy is one of the most dramatic of all physiologic changes, but the factors that are responsible have remained elusive. In rat pregnancy, there are comparable renal hemodynamic changes, and in this species there is comprehensive evidence that the ovarian hormone relaxin (RLX) is responsible. This study investigated the renal effects of recombinant human RLX (rhRLX) in humans. Eleven volunteers (six male, five female) received intravenous infusions of rhRLX over 5 h at an infusion rate that was chosen to sustain serum concentrations that are comparable to early pregnancy. The renal clearances of inulin and para-aminohippurate were used to measure GFR and renal plasma flow, respectively. Irrespective of gender, renal plasma flow was increased by 47% compared with baseline levels (P < 0.0001), but no significant change was observed in GFR. There were no side effects or adverse reactions of rhRLX given as an intravenous infusion, and the data suggest that RLX indeed may be one of the elusive renal vasodilatory factors in human pregnancy. Further work is necessary to elucidate the complimentary factors that permit the concomitant increase in GFR during pregnancy.

Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. Publishing Authors By Initials

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: blood circulation: renal circulation research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: blood circulation: renal circulation research

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Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Society of Nephrology : JA

VOLUME: 17

Page Numbers: 3192-7

Journal Abbreviation: J. Am. Soc. Nephrol.

ISSN: 1046-6673

DAY: 11

MONTH: 10

YEAR: 2006

Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9013836

Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. Keywords Mesh Terms:

KEYWORDS: Renal Circulation

MESH TERMS: drug effects

Chemical & Substance for Abstract: Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. Information

Substance Name: Relaxin

Registry Number: 9002-69-1

Grant and Affiliation Information for Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers.

AFFILIATION: School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK. m.c.smith@ncl.ac.uk

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK63321

ACRONYM: DK

MEDLINETA: J Am Soc Nephrol

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