Influence of prothymosin-alpha on HIV-1 target cells.

Influence of prothymosin-alpha on HIV-1 target cells. Research Abstract Details 

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Influence of prothymosin-alpha on HIV-1 target cells. Abstract Text:

Arevik Mosoian,Avelino Teixeira,Colin S Burns,Gregory Khitrov,Weijia Zhang,Luca Gusella,Paul Klotman,Mary Klotman,Arevik Mosoian,Avelino Teixeira,Colin S Burns,Gregory Khitrov,Weijia Zhang,Luca Gusella,Paul Klotman,Mary Klotman,

The important role of CD8(+) T cells in controlling HIV-1 infection through the innate as well as the adaptive immune system is well established. In addition to the major histocompatibility complex (MHC)-dependent cytotoxic activity of CD8(+) T cells, they produce soluble factors that suppress HIV-1 replication in an MHC-independent manner. Several of those factors have been identified, including beta-chemokines, Rantes, MIP-1alpha, MIP-1beta, and MDC. We previously identified that prothymosin alpha (ProTalpha) in the conditioned medium of HVS transformed CD8(+) T cells was a potent inhibitor of HIV-1 replication following proviral integration. In this report we further characterize the anti-HIV-1 activity of ProTalpha by demonstrating its target-cell specificity, distinction from additional inhibitors of HIV-1 transcription in CD8(+) T cell supernatants, as well as the differential regulation of host cell antiviral genes that could impact HIV-1 replication. These genes include a number of transcription factors as well IFN-alpha-inducible genes including PKR, IRF1, and Rantes, in the absence of induction of IFN-alpha. These data suggest that the anti-HIV-1 activity of ProTalpha is mediated through the modulation of a number of genes that have been reported to suppress HIV-1 replication including the dysregulation of transcription factors and the induction of PKR and Rantes mRNA.

Influence of prothymosin-alpha on HIV-1 target cells. Publishing Authors By Initials

A Mosoian,A Teixeira,CS Burns,G Khitrov,W Zhang,L Gusella,P Klotman,M Klotman,A Mosoian,A Teixeira,CS Burns,G Khitrov,W Zhang,L Gusella,P Klotman,M Klotman,

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Influence of prothymosin-alpha on HIV-1 target cells. Journal Published:

PUBLICATION TYPE: Review

Journal: Annals of the New York Academy of Sciences

VOLUME: 1112

Page Numbers: 269-85

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 28

MONTH: 06

YEAR: 2007

Influence of prothymosin-alpha on HIV-1 target cells. Information

Number of References: 39

LANGUAGE: eng

NlmUniqueID: 7506858

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Grant and Affiliation Information for Influence of prothymosin-alpha on HIV-1 target cells.

AFFILIATION: Division of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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