Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients.

Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients. Research Abstract Details 

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Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients. Abstract Text:

A pharmacokinetic study after a single dose of ceftriaxone, cefoxitin, cefuroxime and ceftazidime was performed to investigate the influence of protein binding and severity of disease on the renal elimination. In intensive-care patients drug-protein binding was substantially less compared to that in volunteers and patients with less complicated diseases. This did not result in increased elimination but, due to increased apparent volumes of distribution, prolonged half-life times were observed. Consequently, in patients with complicated disease states a dosage regimen should be based on pharmacokinetic studies performed in a similar patient group.

Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients. Publishing Authors By Initials

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein binding research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein binding research

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Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmaceutisch weekblad. Scientific edition

VOLUME: 9

Page Numbers: 98-103

Journal Abbreviation:

ISSN: 0167-6555

DAY: 24

MONTH: Apr

YEAR: 1987

Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients. Information

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LANGUAGE: eng

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Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients. Keywords Mesh Terms:

KEYWORDS: Protein Binding

MESH TERMS: urine

Chemical & Substance for Abstract: Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients. Information

Substance Name: Cephalosporins

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Grant and Affiliation Information for Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients.

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Country: NETHERLANDS

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MEDLINETA: Pharm Weekbl Sci

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