Influence of premorbid IQ and education on progression of Alzheimer's disease.

Influence of premorbid IQ and education on progression of Alzheimer's disease. Research Abstract Details 

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Influence of premorbid IQ and education on progression of Alzheimer's disease. Abstract Text:

V N Pavlik,R S Doody,P J Massman,W Chan,V N Pavlik,R S Doody,P J Massman,W Chan,

BACKGROUND: Lower education is associated with a higher risk of developing Alzheimer's disease (AD). Years of education and measures of general intellectual function (IQ) are highly correlated. It is important to determine whether there is a relationship between education and AD outcomes that is independent of IQ. OBJECTIVE: To test the hypothesis that premorbid IQ is a stronger predictor of cognitive decline, global progression, and overall survival, than education in patients with AD. METHODS: The study included 478 probable AD patients (322 women and 156 men, mean age 74.5 years) followed in a large AD referral center for a mean of 3.2 years. Eligible participants had a baseline estimate of premorbid IQ using the American version of the Nelson Adult Reading Test (AMNART) and at least one follow-up visit with complete neuropsychological assessment. We used random effects linear regression analysis, and Cox proportional hazards analysis to determine whether or not education and/or premorbid IQ were independently associated with cognitive decline, global progression of AD, and survival. RESULTS: When the baseline AMNART score was included in regression models along with education and other demographic variables, AMNART score, but not education, was associated with a higher baseline score and slower rate of decline in MMSE and ADAS-Cog scores, and the Clinical Dementia Rating sum of boxes score. Neither higher premorbid IQ nor higher education was associated with longer survival. CONCLUSIONS: We conclude that a baseline AMNART score is a better predictor of cognitive change in AD than education, but neither variable is associated with survival after diagnosis.

Influence of premorbid IQ and education on progression of Alzheimer's disease. Publishing Authors By Initials

VN Pavlik,RS Doody,PJ Massman,W Chan,VN Pavlik,RS Doody,PJ Massman,W Chan,

For similar human activities: survival research abstracts see: human activities: survival research

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Influence of premorbid IQ and education on progression of Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Dementia and geriatric cognitive disorders

VOLUME: 22

Page Numbers: 367-77

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ISSN: 1420-8008

DAY: 5

MONTH: 09

YEAR: 2006

Influence of premorbid IQ and education on progression of Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 9705200

Influence of premorbid IQ and education on progression of Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Survival

MESH TERMS: physiology

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Grant and Affiliation Information for Influence of premorbid IQ and education on progression of Alzheimer's disease.

AFFILIATION: Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX 77098-3926, USA. vpavlik@bcm.tmc.edu

Country: Switzerland

AGENCY: United States PHS

GRANT: AGO-8664

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MEDLINETA: Dement Geriatr Cogn Disord

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