Influence of plasma osmolality on baroreflex control of sympathetic activity.

Influence of plasma osmolality on baroreflex control of sympathetic activity. Research Abstract Details 

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Influence of plasma osmolality on baroreflex control of sympathetic activity. Abstract Text:

Megan M Wenner,William C Rose,Erin P Delaney,Michael E Stillabower,William B Farquhar,Megan M Wenner,William C Rose,Erin P Delaney,Michael E Stillabower,William B Farquhar,

The purpose of this study was to determine if plasma osmolality alters baroreflex control of sympathetic activity when controlling for a change in intravascular volume; we hypothesized that baroreflex control of sympathetic activity would be greater during a hyperosmotic stimulus compared with an isoosmotic stimulus when intravascular volume expansion was matched. Seven healthy subjects (25 +/- 2 yr) completed two intravenous infusions: a hypertonic saline infusion (HSI; 3% NaCl) and, on a separate occasion, an isotonic saline infusion (ISO; 0.9% NaCl), both at a rate of 0.15 ml x kg(-1) x min(-1). To isolate the effect of osmolality, comparisons between HSI and ISO conditions were retrospectively matched based on hematocrit; therefore, baroreflex control of sympathetic outflow was determined at 20 min of a HSI and 40 min of an ISO. Muscle sympathetic outflow (MSNA) was directly measured using the technique of peroneal microneurography; osmolality and blood pressure (Finometer) were assessed. The baroreflex control of sympathetic outflow was estimated by calculating the slope of the relationship between MSNA and diastolic blood pressure during controlled breathing. Plasma osmolality was greater during the HSI compared with the ISO (HSI: 292 +/- 0.9 mosmol/kg and ISO: 289 +/- 0.8 mosmol/kg, P < 0.05). Hematocrits were matched (HSI: 39.1 +/- 1% and ISO: 39.1 +/- 1%, P > 0.40); thus, we were successful in isolating osmolality. The baroreflex control of sympathetic outflow was greater during the HSI compared with the ISO (HSI: -8.3 +/- 1.2 arbitrary units x beat(-1) x mmHg(-1) vs. ISO: -4.0 +/- 0.8 arbitrary units x beat(-1) x mmHg(-1), P = 0.01). In conclusion, when controlling for intravascular volume, increased plasma osmolality enhances baroreflex control of sympathetic activity in humans.

Influence of plasma osmolality on baroreflex control of sympathetic activity. Publishing Authors By Initials

MM Wenner,WC Rose,EP Delaney,ME Stillabower,WB Farquhar,MM Wenner,WC Rose,EP Delaney,ME Stillabower,WB Farquhar,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Influence of plasma osmolality on baroreflex control of sympathetic activity. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Heart and circulat

VOLUME: 293

Page Numbers: H2313-9

Journal Abbreviation: Am. J. Physiol. Heart Circ. Ph

ISSN: 0363-6135

DAY: 20

MONTH: 07

YEAR: 2007

Influence of plasma osmolality on baroreflex control of sympathetic activity. Information

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LANGUAGE: eng

NlmUniqueID: 100901228

Influence of plasma osmolality on baroreflex control of sympathetic activity. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Influence of plasma osmolality on baroreflex control of sympathetic activity. Information

Substance Name: Sodium Chloride

Registry Number: 7647-14-5

Grant and Affiliation Information for Influence of plasma osmolality on baroreflex control of sympathetic activity.

AFFILIATION: Department of Health, Nutrition, College of Health Sciences, University of Delaware, Delaware 19716, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: 1-R15-HL-074851-01

ACRONYM: HL

MEDLINETA: Am J Physiol Heart Circ Physio

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