Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats.

Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats. Abstract Text:

Four groups of Sprague-Dawley rats were anaesthetized with isoflurane (ISO) (1.7% end-tidal concentration) in 40% oxygen, and mechanically ventilated. The animals were bled 15 mL kg-1 b.w. from the femoral vein over 10 min, followed by an observation period of 30 min. Ten minutes before haemorrhage each group of animals was pre-treated with intravenous injection/infusion of either: isotonic saline (Group B; CON; n=7), vasopressin V1-receptor antagonist [d(CH2)5Tyr(Me)AVP; 10 microg kg-1] (Group C; AVP-a; n=7), the non-selective angiotensin II receptor antagonist saralasin (10 microg kg-1 min-1) (Group D; SAR; n=7) or hexamethonium (10 mg kg-1) (Group E; HEX; n=7). A separate group of conscious animals were pre-treated with isotonic NaCl and subjected to the same haemorrhage protocol (Group A; AW; n=7). Mean arterial pressure (MAP), heart rate (HR) and blood gases were observed during the experiments. Only pre-treatment with SAR and HEX reduced MAP significantly. The pre-haemorrhage HR was only affected by HEX, which caused a reduction by 17%. The HR was significantly lower at the end of haemorrhage compared with pre-haemorrhage levels in all groups except that group treated with HEX. In that group the HR changed in the opposite direction. The ability to maintain MAP during haemorrhage, and the post-haemorrhage period, was significantly impaired in the groups treated with AVP-a, SAR or HEX compared with the group receiving NaCl. It is concluded that autonomic nervous activity is of major importance for the maintenance of MAP during isoflurane anaesthesia, whereas circulating angiotensin II and vasopressin levels contribute to a much smaller degree in this regard. General anaesthesia in combination with different degrees of neurohumoral blockade impairs the haemodynamic responses to blood loss, seen in conscious individuals. The impairment involves both the early and late phases during haemorrhage, as well as the post-bleeding recovery period. All three neurohumoral systems (autonomic nervous activity, angiotensin II and vasopressin) are of importance for regulating MAP during and after haemorrhage, although the autonomic nervous outflow appears to contribute to a larger extent.

Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta physiologica Scandinavica

VOLUME: 169

Page Numbers: 189-94

Journal Abbreviation: Acta Physiol. Scand.

ISSN: 0001-6772

DAY: 16

MONTH: Jul

YEAR: 2000

Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370362

Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats. Keywords Mesh Terms:

KEYWORDS: Saralasin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats. Information

Substance Name: vasopressin, 1-(1-mercaptocyclohexaneace

Registry Number: 73168-24-8

Grant and Affiliation Information for Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats.

AFFILIATION: Department of Anesthesiology, Oregon Health Sciences University, Portland, Oregon, USA.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Physiol Scand

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats Related Publications

• Analysis of RNA export using Xenopus oocytes.
• Assessing risk of reoffending in adolescents who have committed a sexual offense: the accuracy of clinical judgments after completion of risk assessment instruments.
• Biochemical and physiological properties of isolated platelet membranes.
• Brief report: enhanced picture naming in autism.
• Chromoendoscopy should be the standard method and more widely used for cancer surveillance colonoscopy in ulcerative colitis--con.
• Class-based feature matching across unrestricted transformations.
• Commentary.
• Comparing gang and individual rapes in a community sample of urban women.
• Discoid and subacute lupus erythematosus treated with 0.5% R-salbutamol cream.
• Disparities in inflammatory bowel disease care: time to correct a problem.
• Double dissociation between rules and memory in music: an event-related potential study.
• Dream.
• Functional characterization of nucleoside transporter gene replacements in Leishmania donovani.
• Genetic selection for a highly functional cysteine-less membrane protein using site saturation mutagenesis.
• Image interpretation by a single bottom-up top-down cycle.
• Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats.
• Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs.
• METHENAMINE MANDELATE (MANDELAMINE) IN URINARY TRACT INFECTIONS.
• Molecular characterization of the Ran-binding zinc finger domain of Nup153.
• Not Available
• Nuclear envelope breakdown is coordinated by both Nup358/RanBP2 and Nup153, two nucleoporins with zinc finger modules.
• One thousand unsuccessful careers.
• Purine and pyrimidine metabolism in Leishmania.
• Speeded processing of grammar and tool knowledge in Tourette's syndrome.
• Structural equation modeling: reviewing the basics and moving forward.
• The aged: satisfied or dissatisfied?
• The inhibitory and necrosis-inducing effects of the latex of Ficus carica L. on transplanted and spontaneous tumours.
• Vasopressin and angiotensin II in blood pressure control during isoflurane anesthesia in rats.