Influence of hysterectomy on long-term fracture risk.

Influence of hysterectomy on long-term fracture risk. Research Abstract Details 

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Influence of hysterectomy on long-term fracture risk. Abstract Text:

L Joseph Melton,Sara J Achenbach,John B Gebhart,Ebenezer O Babalola,Elizabeth J Atkinson,Adil E Bharucha,

OBJECTIVE: To assess long-term fracture risk after hysterectomy, with or without oophorectomy. DESIGN: Population-based, cohort study. SETTING: Olmsted County, Minnesota. PATIENT(S): Women residing in Olmsted County (n = 9,258) who underwent hysterectomy in 1965-2002, compared to an equal number of age- and sex-matched community controls. INTERVENTION(S): Observational study of the effect of hysterectomy for various indications on subsequent fractures. MAIN OUTCOME MEASURE(S): Fractures of any type, and at osteoporotic sites (e.g., hip, spine, or wrist) alone, as assessed by electronic review of inpatient and outpatient diagnoses in the community. RESULT(S): Compared with controls, there was a significant increase (hazard ratio [HR], 1.21; 95% confidence interval [CI], 1.13-1.29) in overall fracture risk among the women with a hysterectomy, but osteoporotic fracture risk was not elevated (HR, 1.09; 95% CI, 0.98-1.22). Most hysterectomy indications were associated with fractures generally, although these were not often statistically significant. Only operations for a uterine prolapse were associated with osteoporotic fractures (HR, 1.33; 95% CI, 1.01-1.74). Oophorectomy was not an independent predictor of fracture risk (HR, 1.0; 95% CI, 0.98-1.15). CONCLUSION(S): Hysterectomy does not appear to pose much long-term risk for fractures, but the association of fractures with surgery for uterine prolapse deserves further attention.

Influence of hysterectomy on long-term fracture risk. Publishing Authors By Initials

LJ Melton,SJ Achenbach,JB Gebhart,EO Babalola,EJ Atkinson,AE Bharucha,

For similar natural sciences: time research abstracts see: natural sciences: time research

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Influence of hysterectomy on long-term fracture risk. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Fertility and sterility

VOLUME: 88

Page Numbers: 156-62

Journal Abbreviation: Fertil. Steril.

ISSN: 1556-5653

DAY: 30

MONTH: 01

YEAR: 2007

Influence of hysterectomy on long-term fracture risk. Information

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LANGUAGE: eng

NlmUniqueID: 372772

Influence of hysterectomy on long-term fracture risk. Keywords Mesh Terms:

KEYWORDS: Time

MESH TERMS: trends

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Grant and Affiliation Information for Influence of hysterectomy on long-term fracture risk.

AFFILIATION: Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. melton.j@mayo.edu

Country: United States

AGENCY: United States NICHD

GRANT: HD41129

ACRONYM: HD

MEDLINETA: Fertil Steril

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