[Influence of hyperoxic fluid on the down-regulated proteins of intestinal mucosa in scalded rats]

[Influence of hyperoxic fluid on the down-regulated proteins of intestinal mucosa in scalded rats] Research Abstract Details 

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[Influence of hyperoxic fluid on the down-regulated proteins of intestinal mucosa in scalded rats] Abstract Text:

Xiao-Jun Wang,Yong-Hua Sun,Jian-Ning Wang,Qin-Xue Ding,Li-Ping Zhang,Guo-Cheng Song,Hong Xiao,

OBJECTIVE: To investigate the influence of hyperoxic fluid on the down-regulated proteins of intestinal mucosa in scalded rats, so as to provide a theoretical basis for the clinical use of hyperoxic fluid. METHODS: Sprague-Dawley (SD) rats with 35% TBSA full-thickness scald were randomly divided into scald control (S, n = 6,with intraperitoneal fluid infusion after scalding), hyperoxic (H, n = 6, with hyperoxic fluid infusion after scalding) groups. Six rats without scald injury served as normal group. The proteins in the intestinal mucosa were separated with the two-dimensional electrophoresis (2-DE), and were analyzed with ImageMaster 2D Elite. The influence of hyperoxic fluid on the down-regulated proteins of intestinal mucosa in scalded rats was studied with bio-spectrum, protein bank and document analysis. RESULTS: (1) Among the 34 down-regulated protein spots in S group, 9 of them definitely exhibited up-regulation compared with those in H group. (2) The expression of mitochondrial aconitase, alpha-propionyl-CoA carboxylase, short chain of hydroxylacyl-Coenzyme A dehydrogenase, transcription factor EB (estradiol benzoate), triosephosphate isomerase 1, T cell receptor V delta 6, and dynein-like protein-5 in H group were significantly up-regulated. CONCLUSION: The hyperoxic fluid could up-regulate the down-regulated proteins in rat intestinal mucosa at early postburn stage, so that the barrier function of intestinal mucosa of rats with severe burns could be partially recovered.

[Influence of hyperoxic fluid on the down-regulated proteins of intestinal mucosa in scalded rats] Publishing Authors By Initials

XJ Wang,YH Sun,JN Wang,QX Ding,LP Zhang,GC Song,H Xiao,

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[Influence of hyperoxic fluid on the down-regulated proteins of intestinal mucosa in scalded rats] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang za

VOLUME: 21

Page Numbers: 60-2

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ISSN: 1009-2587

DAY: 30

MONTH: Feb

YEAR: 2005

[Influence of hyperoxic fluid on the down-regulated proteins of intestinal mucosa in scalded rats] Information

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LANGUAGE: chi

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AFFILIATION: General Surgery Department, The Sixth Municipal Hospital of Beijing, Beijing 100007, P.R. China.

Country: China

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MEDLINETA: Zhonghua Shao Shang Za Zhi

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