Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells.

Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells. Research Abstract Details 

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Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells. Abstract Text:

Gretchen E Lyons,Tamson Moore,Natasha Brasic,Mingli Li,Jeffrey J Roszkowski,Michael I Nishimura,

The CD8 coreceptor on T cells has two functions. Namely, CD8 acts to stabilize the binding of the T-cell receptor (TCR) to the peptide-MHC complex while localizing p56(lck) (lck) to the TCR/CD3 complex to facilitate early signaling events. Although both functions may be critical for efficient activation of a CTL, little is known about how the structural versus signaling roles of CD8, together with the relative strength of the TCR, influences T-cell function. We have addressed these issues by introducing full-length and truncated versions of the CD8alpha and CD8beta chains into CD8(-) Jurkat cell clones expressing cloned TCRs with known antigen specificity and relative affinities. Using a combination of antigen recognition and tetramer-binding assays, we find that the intracellular lck-binding domain of CD8 is critical for enhanced T-cell activation regardless of the relative strength of the TCR. In contrast, the extracellular domain of CD8 seems to be critical for TCRs with lower affinity but not those with higher affinity. Based on our results, we conclude that there are different requirements for CD8 to enhance T-cell function depending on the strength of its TCR.

Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells. Publishing Authors By Initials

GE Lyons,T Moore,N Brasic,M Li,JJ Roszkowski,MI Nishimura,

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer research

VOLUME: 66

Page Numbers: 11455-61

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 1

MONTH: Dec

YEAR: 2006

Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: metabolism

Chemical & Substance for Abstract: Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells. Information

Substance Name: Lymphocyte Specific Protein Tyrosine Kin

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells.

AFFILIATION: Department of Surgery, The University of Chicago, Chicago, Illinois, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA90873

ACRONYM: CA

MEDLINETA: Cancer Res

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