Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat.

Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat. Research Abstract Details 

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Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat. Abstract Text:

Hiroshi Nagabukuro,Karen J Berkley,Hiroshi Nagabukuro,Karen J Berkley,

This study examined pseudoaffective responses elicited by vaginal distention in urethane-anesthetized rats, and tested hypotheses that responses would be increased by endometriosis (ENDO) and vary with the estrous cycle. Three groups were studied: ENDO, shamENDO, and Naive. ENDO was induced by autotransplanting small pieces of uterine horn (or, for shamENDO, fat) on mesenteric arteries. Ten weeks later, rats in proestrus or metestrus were anesthetized with urethane. Distendable latex balloons were inserted into the vaginal canal. While an increasing series of vaginal distentions was delivered, changes in electromyographic activity of the external oblique musculature (visceromotor response, VMR) and mean arterial pressure (pressor) responses were simultaneously measured. Vaginal distention produced VMR and pressor responses in all groups. These responses were significantly greater in ENDO than in the other groups, and greater in proestrus than metestrus. Although the overall amount of cystic tissue was greater in proestrous than metestrous rats, there was no correlation between these amounts and VMR or pressor responses. Acute spinalization (T8-T9) and bilateral pelvic, but not hypogastric, neurectomy attenuated both VMR and pressor responses, supporting the hypothesis that vaginal nociception involves suprathoracic spinal processing of information conveyed by the pelvic nerve. These effects on VMR and pressor responses to vaginal distention parallel behavioral escape responses to the same stimuli reported previously. The findings encourage continued use of VMR and pressor responses for further investigation of mechanisms underlying pain associated with ENDO and its potential treatment.

Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat. Publishing Authors By Initials

H Nagabukuro,KJ Berkley,H Nagabukuro,KJ Berkley,

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Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pain

VOLUME: 132 Suppl 1

Page Numbers: S96-103

Journal Abbreviation: Pain

ISSN: 1872-6623

DAY: 1

MONTH: 06

YEAR: 2007

Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat. Information

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LANGUAGE: eng

NlmUniqueID: 7508686

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Grant and Affiliation Information for Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat.

AFFILIATION: Program in Neuroscience, Florida State University, Tallahassee, FL 32306-1270, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: R01 NS11892

ACRONYM: NS

MEDLINETA: Pain

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