Influence of diltiazem on cardiac function at organ and molecular level during hypothermic cardiac arrest.

Influence of diltiazem on cardiac function at organ and molecular level during hypothermic cardiac arrest. Research Abstract Details 

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Influence of diltiazem on cardiac function at organ and molecular level during hypothermic cardiac arrest. Abstract Text:

K Prasad,B Bharadwa,

The present study was undertaken to assess the effects of cold crystalloid cardioplegia with and without diltiazem on the functional recovery of the heart, calcium binding and uptake by the sarcoplasmic reticulum, Ca++ATPase of sarcoplasmic reticulum and coronary sinus serum MBCK (MB fraction of creatine kinase) of dogs, after 1.5 h of reperfusion following 1 h of ischemic cardiac arrest. The dogs were divided into three groups: group I, sham bypass (no ischemic cardiac arrest); group II, cold crystalloid cardioplegia; group III, cold crystalloid cardioplegia with diltiazem. The results showed that the decrease in the index of cardiac contractility and cardiac index which accompanies cold crystalloid cardioplegia is associated with a decrease in the calcium uptake by sarcoplasmic reticulum. The index of myocardial contractility was better preserved with cold crystalloid plus diltiazem than with cold crystalloid alone. This improvement, although partial, in cardiac contractility with cold crystalloid plus diltiazem, was associated with a tendency for an increase towards control values in the calcium uptake by sarcoplasmic reticulum. There were no changes in Ca++ATPase of, and calcium binding by, the sarcoplasmic reticulum of groups II and III when compared to group I. There was a progressive increase in the MBCK of coronary sinus blood in groups II and III. The MBCK of group I was unchanged throughout the experimental protocol. The increases in the MBCK of coronary sinus blood were less in group III than in group II indicating the protective effect of diltiazem on ischemic and reperfusion myocardial injury.(ABSTRACT TRUNCATED AT 250 WORDS)

Influence of diltiazem on cardiac function at organ and molecular level during hypothermic cardiac arrest. Publishing Authors By Initials

K Prasad,B Bharadwa,

For similar musculoskeletal system: muscles: muscle, skeletal: sarcoplasmic reticulum research abstracts see: musculoskeletal system: muscles: muscle, skeletal: sarcoplasmic reticulum research

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Influence of diltiazem on cardiac function at organ and molecular level during hypothermic cardiac arrest. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Canadian journal of cardiology

VOLUME: 3

Page Numbers: 351-6

Journal Abbreviation:

ISSN: 1916-7075

DAY: 3

MONTH: Oct

YEAR: 1987

Influence of diltiazem on cardiac function at organ and molecular level during hypothermic cardiac arrest. Information

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LANGUAGE: eng

NlmUniqueID: 8510280

Influence of diltiazem on cardiac function at organ and molecular level during hypothermic cardiac arrest. Keywords Mesh Terms:

KEYWORDS: Sarcoplasmic Reticulum

MESH TERMS: metabolism

Chemical & Substance for Abstract: Influence of diltiazem on cardiac function at organ and molecular level during hypothermic cardiac arrest. Information

Substance Name: Calcium-Transporting ATPases

Registry Number: EC 3.6.1.8

Grant and Affiliation Information for Influence of diltiazem on cardiac function at organ and molecular level during hypothermic cardiac arrest.

AFFILIATION: Department of Physiology and Cardiovascular Surgery, College of Medicine, University of Saskatchewan, Saskatoon.

Country: CANADA

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MEDLINETA: Can J Cardiol

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