Influence of antibody formation on reduction of globotriaosylceramide (GL-3) in urine from Fabry patients during agalsidase beta therapy.

Influence of antibody formation on reduction of globotriaosylceramide (GL-3) in urine from Fabry patients during agalsidase beta therapy. Research Abstract Details 

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Influence of antibody formation on reduction of globotriaosylceramide (GL-3) in urine from Fabry patients during agalsidase beta therapy. Abstract Text:

Toya Ohashi,Mio Sakuma,Teruo Kitagawa,Ken Suzuki,Nobuyuki Ishige,Yoshikatsu Eto,Toya Ohashi,Mio Sakuma,Teruo Kitagawa,Ken Suzuki,Nobuyuki Ishige,Yoshikatsu Eto,Toya Ohashi,Mio Sakuma,Teruo Kitagawa,Ken Suzuki,Nobuyuki Ishige,Yoshikatsu Eto,

Two recombinant human agalsidase preparations are available for treatment of Fabry disease. We assayed urinary GL-3 (uGL-3) concentration in seronegative and seropositive patients receiving agalsidase beta (1mg/kg). Antibody formation and residual enzyme activity were strongly correlated. Normalization of uGL-3 was achieved more efficiently in seronegatives. But different from previous reports, reduction of uGL-3 level was observed in some seropositive patients.

Influence of antibody formation on reduction of globotriaosylceramide (GL-3) in urine from Fabry patients during agalsidase beta therapy. Publishing Authors By Initials

T Ohashi,M Sakuma,T Kitagawa,K Suzuki,N Ishige,Y Eto,T Ohashi,M Sakuma,T Kitagawa,K Suzuki,N Ishige,Y Eto,T Ohashi,M Sakuma,T Kitagawa,K Suzuki,N Ishige,Y Eto,

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Influence of antibody formation on reduction of globotriaosylceramide (GL-3) in urine from Fabry patients during agalsidase beta therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular genetics and metabolism

VOLUME: 92

Page Numbers: 271-3

Journal Abbreviation: Mol. Genet. Metab.

ISSN: 1096-7192

DAY: 8

MONTH: 08

YEAR: 2007

Influence of antibody formation on reduction of globotriaosylceramide (GL-3) in urine from Fabry patients during agalsidase beta therapy. Information

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LANGUAGE: eng

NlmUniqueID: 9805456

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Grant and Affiliation Information for Influence of antibody formation on reduction of globotriaosylceramide (GL-3) in urine from Fabry patients during agalsidase beta therapy.

AFFILIATION: Department of Gene Therapy, Institute of DNA Medicine, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minatoku, Tokyo 105-8461, Japan. tohashi@jikei.ac.jp

Country: United States

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MEDLINETA: Mol Genet Metab

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