Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients.

Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients. Research Abstract Details 

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Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients. Abstract Text:

The effects of age and co-medication on steady-state phenobarbital (PB) level-dose (L/D) ratios were evaluated retrospectively in 539 paediatric patients. The PB L/D ratio increased significantly with age up to 15 years. Associated anti-epileptic therapy affected the PB L/D ratio, which was significantly increased in patients on polypharmacy as compared to patients on monopharmacy. Therefore, routine monitoring of PB serum levels is extremely useful, particularly in the paediatric age group, and in patients who require associated anti-epileptic medication.

Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients. Publishing Authors By Initials

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidinones: barbiturates: phenobarbital research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidinones: barbiturates: phenobarbital research

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Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 17

Page Numbers: 249-53

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Aug

YEAR: 1992

Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients. Information

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LANGUAGE: eng

NlmUniqueID: 8704308

Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients. Keywords Mesh Terms:

KEYWORDS: Phenobarbital

MESH TERMS: blood

Chemical & Substance for Abstract: Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients. Information

Substance Name: Phenobarbital

Registry Number: 50-06-6

Grant and Affiliation Information for Influence of age and co-medication on steady-state phenobarbital serum level-dose ratios in Japanese paediatric patients.

AFFILIATION: Department of Hospital Pharmacy, Kyushu University Hospital, Faculty of Medicine, Fukuoka, Japan.

Country: ENGLAND

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MEDLINETA: J Clin Pharm Ther

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