Inflammatory changes parallel the early stages of Alzheimer disease.

Inflammatory changes parallel the early stages of Alzheimer disease. Research Abstract Details 

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Inflammatory changes parallel the early stages of Alzheimer disease. Abstract Text:

A Parachikova,M G Agadjanyan,D H Cribbs,M Blurton-Jones,V Perreau,J Rogers,T G Beach,C W Cotman,

Alzheimer disease (AD) is the most prominent cause of dementia in the elderly. To determine changes in the AD brain that may mediate the transition into dementia, the gene expression of approximately 10,000 full-length genes was compared in mild/moderate dementia cases to non-demented controls that exhibited high AD pathology. Including this latter group distinguishes this work from previous studies in that it allows analysis of early cognitive loss. Compared to non-demented high-pathology controls, the hippocampus of AD cases with mild/moderate dementia had increased gene expression of the inflammatory molecule major histocompatibility complex (MHC) II, as assessed with microarray analysis. MHC II protein levels were also increased and inversely correlated with cognitive ability. Interestingly, the mild/moderate AD dementia cases also exhibited decreased number of T cells in the hippocampus and the cortex compared to controls. In conclusion, transition into AD dementia correlates with increased MHC II(+) microglia-mediated immunity and is paradoxically paralleled by a decrease in T cell number, suggesting immune dysfunction.

Inflammatory changes parallel the early stages of Alzheimer disease. Publishing Authors By Initials

A Parachikova,MG Agadjanyan,DH Cribbs,M Blurton-Jones,V Perreau,J Rogers,TG Beach,CW Cotman,

For similar animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research abstracts see: animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research

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Inflammatory changes parallel the early stages of Alzheimer disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 1821-33

Journal Abbreviation: Neurobiol. Aging

ISSN: 1558-1497

DAY: 18

MONTH: 10

YEAR: 2006

Inflammatory changes parallel the early stages of Alzheimer disease. Information

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LANGUAGE: eng

NlmUniqueID: 8100437

Inflammatory changes parallel the early stages of Alzheimer disease. Keywords Mesh Terms:

KEYWORDS: Humans

MESH TERMS: immunology

Chemical & Substance for Abstract: Inflammatory changes parallel the early stages of Alzheimer disease. Information

Substance Name: Cytokines

Registry Number: 0

Grant and Affiliation Information for Inflammatory changes parallel the early stages of Alzheimer disease.

AFFILIATION: Institute for Brain Aging & Dementia, University of California, 1113 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4540, USA. aparachi@uci.edu

Country: United States

AGENCY: United States NIA

GRANT: P30 AG19610

ACRONYM: AG

MEDLINETA: Neurobiol Aging

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