Inflammation-specific T1 imaging using anti-intercellular adhesion molecule 1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid.

Inflammation-specific T1 imaging using anti-intercellular adhesion molecule 1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid. Research Abstract Details 

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Inflammation-specific T1 imaging using anti-intercellular adhesion molecule 1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid. Abstract Text:

Kyu-Sil Choi,Sun-Hee Kim,Quan-Yu Cai,Soo-Yeon Kim,Hyang-Ok Kim,Hye-Jin Lee,Eun-A Kim,Seong-Eon Yoon,Ki-Jung Yun,Kwon-Ha Yoon,Kyu-Sil Choi,Sun-Hee Kim,Quan-Yu Cai,Soo-Yeon Kim,Hyang-Ok Kim,Hye-Jin Lee,Eun-A Kim,Seong-Eon Yoon,Ki-Jung Yun,Kwon-Ha Yoon,

To examine inflammatory tissue, an initial and common symptom of various types of pathogenesis, we designed inflammation-targeted T(1) contrast agents prepared by bioconjugation of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) with anti-intercellular adhesion molecule 1 (ICAM-1) antibody. The anti-ICAM-1 antibody was coupled with DTPA and was then conjugated with Gd. The specific binding of the Gd-DTPA-anti-ICAM-1 antibody complex to the ICAM-1-expressing cells was examined in the cultured endothelial cells where ICAM-1 expression was stimulated. Inflammation-specific T(1) imaging was then assessed using a mouse abscess model with the 1.5-Tesla module. The Gd-DTPA-anti-ICAM-1 antibody displayed increased r1, which was two times higher than that of Gd-DTPA and showed predominant binding to cultured endothelial cells, which expressed a high level of ICAM-1. Moreover, the inflammation-specific T(1) enhancement was imaged with the Gd-DTPA-anti-ICAM-1 antibody in the mouse acute inflammation model. The Gd-DTPA-anti-ICAM-1 antibody showed significantly increased vascular circulation time, which thereby offered a greater chance for its binding to the target cells. The Gd-DTPA-anti-ICAM-1 antibody displays a potential targeted T(1) contrast agent specific to the inflammatory tissue that expresses ICAM-1.

Inflammation-specific T1 imaging using anti-intercellular adhesion molecule 1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid. Publishing Authors By Initials

KS Choi,SH Kim,QY Cai,SY Kim,HO Kim,HJ Lee,EA Kim,SE Yoon,KJ Yun,KH Yoon,KS Choi,SH Kim,QY Cai,SY Kim,HO Kim,HJ Lee,EA Kim,SE Yoon,KJ Yun,KH Yoon,

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Inflammation-specific T1 imaging using anti-intercellular adhesion molecule 1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular imaging : official journal of the Societ

VOLUME: 6

Page Numbers: 75-84

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ISSN: 1535-3508

DAY: 20

MONTH: 04

YEAR: 2007

Inflammation-specific T1 imaging using anti-intercellular adhesion molecule 1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid. Information

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LANGUAGE: eng

NlmUniqueID: 101120118

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Grant and Affiliation Information for Inflammation-specific T1 imaging using anti-intercellular adhesion molecule 1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid.

AFFILIATION: Department of Radiology and Institute for Radiological Imaging Science, Wonkwang University School of Medicine, Iksan, Jeonbuk, South Korea.

Country: United States

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MEDLINETA: Mol Imaging

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