Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis.

Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. Research Abstract Details 

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Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. Abstract Text:

Lisa K Peterson,Robert S Fujinami,

Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions, there has been a major focus on understanding mechanisms of demyelination. However, identification of markers for axonal damage and development of new imaging techniques has enabled detection of subtle changes in axonal pathology and revived interest in the neurodegenerative component of MS. Axonal loss is generally accepted as the main determinant of permanent clinical disability. However, the role of axonal loss early in disease or during relapsing-remitting disease is still under investigation, as are the interactions and interdependency between inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of MS.

Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. Publishing Authors By Initials

LK Peterson,RS Fujinami,

For similar pathological conditions, signs and symptoms: pathologic processes: nerve degeneration research abstracts see: pathological conditions, signs and symptoms: pathologic processes: nerve degeneration research

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Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of neuroimmunology

VOLUME: 184

Page Numbers: 37-44

Journal Abbreviation: J. Neuroimmunol.

ISSN: 0165-5728

DAY: 28

MONTH: 12

YEAR: 2006

Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. Information

Number of References: 81

LANGUAGE: eng

NlmUniqueID: 8109498

Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. Keywords Mesh Terms:

KEYWORDS: Nerve Degeneration

MESH TERMS: prevention & control

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Grant and Affiliation Information for Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis.

AFFILIATION: Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132-2305, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: R01 NS040350-04

ACRONYM: NS

MEDLINETA: J Neuroimmunol

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