Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo.

Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. Research Abstract Details 

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Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. Abstract Text:

Lloyd S Miller,Eric M Pietras,Lawrence H Uricchio,Kathleen Hirano,Shyam Rao,Heping Lin,Ryan M O'Connell,Yoichiro Iwakura,Ambrose L Cheung,Genhong Cheng,Robert L Modlin,Lloyd S Miller,Eric M Pietras,Lawrence H Uricchio,Kathleen Hirano,Shyam Rao,Heping Lin,Ryan M O'Connell,Yoichiro Iwakura,Ambrose L Cheung,Genhong Cheng,Robert L Modlin,Lloyd S Miller,Eric M Pietras,Lawrence H Uricchio,Kathleen Hirano,Shyam Rao,Heping Lin,Ryan M O'Connell,Yoichiro Iwakura,Ambrose L Cheung,Genhong Cheng,Robert L Modlin,

IL-1R activation is required for neutrophil recruitment in an effective innate immune response against Staphylococcus aureus infection. In this study, we investigated the mechanism of IL-1R activation in vivo in a model of S. aureus infection. In response to a S. aureus cutaneous challenge, mice deficient in IL-1beta, IL-1alpha/IL-1beta, but not IL-1alpha, developed larger lesions with higher bacterial counts and had decreased neutrophil recruitment compared with wild-type mice. Neutrophil recruitment and bacterial clearance required IL-1beta expression by bone marrow (BM)-derived cells and not by non-BM-derived resident cells. In addition, mice deficient in the inflammasome component apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) had the same defects in neutrophil recruitment and host defense as IL-1beta-deficient mice, demonstrating an essential role for the inflammasome in mediating the production of active IL-1beta to promote neutrophil recruitment in host defense against S. aureus. This finding was further supported by the ability of recombinant active IL-1beta to control the infection and promote bacterial clearance in IL-1beta-deficient mice. These studies define a key host defense circuit where inflammasome-mediated IL-1beta production by BM-derived cells signals IL-1R on non-BM-derived resident cells to activate neutrophil recruitment in the innate immune response against S. aureus in vivo.

Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. Publishing Authors By Initials

LS Miller,EM Pietras,LH Uricchio,K Hirano,S Rao,H Lin,RM O'Connell,Y Iwakura,AL Cheung,G Cheng,RL Modlin,LS Miller,EM Pietras,LH Uricchio,K Hirano,S Rao,H Lin,RM O'Connell,Y Iwakura,AL Cheung,G Cheng,RL Modlin,LS Miller,EM Pietras,LH Uricchio,K Hirano,S Rao,H Lin,RM O'Connell,Y Iwakura,AL Cheung,G Cheng,RL Modlin,

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Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 6933-42

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Nov

YEAR: 2007

Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

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Grant and Affiliation Information for Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo.

AFFILIATION: Division of Dermatology, University of California, Los Angeles, CA 90095, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA87924

ACRONYM: CA

MEDLINETA: J Immunol

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