Inferring protein-protein interaction networks from protein complex data.

Inferring protein-protein interaction networks from protein complex data. Research Abstract Details 

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Inferring protein-protein interaction networks from protein complex data. Abstract Text:

Shawn Martin,Zisu Mao,Linda S Chan,Suraiya Rasheed,Shawn Martin,Zisu Mao,Linda S Chan,Suraiya Rasheed,Shawn Martin,Zisu Mao,Linda S Chan,Suraiya Rasheed,

Present day approaches for the determination of protein-protein interaction networks are usually based on two hybrid experimental measurements. Here we consider a computational method that uses another type of experimental data: instead of direct information about protein-protein interactions, we consider data in the form of protein complexes. We propose a method for using these complexes to provide predictions of protein-protein interactions. When applied to a dataset obtained from a cat melanoma cell line we find that we are able to predict when a protein pair belongs to a complex with approximately 96% accuracy. Further, we are able to extrapolate the experimentally identified interaction pairs to the entire cat proteome.

Inferring protein-protein interaction networks from protein complex data. Publishing Authors By Initials

S Martin,Z Mao,LS Chan,S Rasheed,S Martin,Z Mao,LS Chan,S Rasheed,S Martin,Z Mao,LS Chan,S Rasheed,

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Inferring protein-protein interaction networks from protein complex data. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of bioinformatics research a

VOLUME: 3

Page Numbers: 480-92

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ISSN: 1744-5485

DAY: 30

MONTH: 11

YEAR: 2007

Inferring protein-protein interaction networks from protein complex data. Information

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LANGUAGE: eng

NlmUniqueID: 101253758

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Grant and Affiliation Information for Inferring protein-protein interaction networks from protein complex data.

AFFILIATION: Department of Computational Biology,Sandia National Laboratories, Albuquerque, NM 87185-1316, USA.

Country: Switzerland

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MEDLINETA: Int J Bioinform Res Appl

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