Infections caused by coryneform bacteria in pediatric oncology patients.

Infections caused by coryneform bacteria in pediatric oncology patients. Research Abstract Details 

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Infections caused by coryneform bacteria in pediatric oncology patients. Abstract Text:

BACKGROUND: Invasive infections caused by coryneform bacteria are uncommon but have been reported with increasing frequency in recent decades, especially in immunocompromised persons. Because pediatric experience is limited, we examined the epidemiology and clinical characteristics of these infections in children undergoing cancer therapy. METHODS: Using strict case definitions, 17 coryneform bacterial infections were identified in 16 children during a 13-year period; there were 12 episodes of bacteremia and 5 skin or soft tissue infections. RESULTS: The median age of children with bloodstream infections was 11.2 years, and that of children with skin or soft tissue infections was 3.5 years. Most were receiving cancer therapy at the time of their infections, were outpatients at the onset of their infections, had central venous catheters, and were not neutropenic. No patient died as a result of infection and most had relatively mild signs and symptoms. All patients responded promptly to antimicrobial therapy and, although 3 infections relapsed, there was only 1 serious complication. The most common species isolated were Corynebacterium striatum, C. amycolatum, and Microbacterium species. CONCLUSIONS: The epidemiologic and clinical features of coryneform bacterial infections in immunocompromised children differ in several important respects from the previously reported characteristics of these infections in adults.

Infections caused by coryneform bacteria in pediatric oncology patients. Publishing Authors By Initials

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Infections caused by coryneform bacteria in pediatric oncology patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Pediatric infectious disease journal

VOLUME: 27

Page Numbers: 136-41

Journal Abbreviation: Pediatr. Infect. Dis. J.

ISSN: 0891-3668

DAY: 21

MONTH: Feb

YEAR: 2008

Infections caused by coryneform bacteria in pediatric oncology patients. Information

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LANGUAGE: eng

NlmUniqueID: 8701858

Infections caused by coryneform bacteria in pediatric oncology patients. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Infections caused by coryneform bacteria in pediatric oncology patients. Information

Substance Name: Antineoplastic Agents

Registry Number: 0

Grant and Affiliation Information for Infections caused by coryneform bacteria in pediatric oncology patients.

AFFILIATION: Department of Infectious Diseases, St. Jude Children's Research Hospital, Department of Molecular Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38105, USA. elisabeth.adderson@stjude.org

Country: United States

AGENCY: United States NCI

GRANT: CA21765

ACRONYM: CA

MEDLINETA: Pediatr Infect Dis J

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