Infected cell carriers: a new strategy for systemic delivery of oncolytic measles viruses in cancer virotherapy.

Infected cell carriers: a new strategy for systemic delivery of oncolytic measles viruses in cancer virotherapy. Research Abstract Details 

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Infected cell carriers: a new strategy for systemic delivery of oncolytic measles viruses in cancer virotherapy. Abstract Text:

Ianko D Iankov,Boris Blechacz,Chunsheng Liu,Jeffrey D Schmeckpeper,James E Tarara,Mark J Federspiel,Noel Caplice,Stephen J Russell,Ianko D Iankov,Boris Blechacz,Chunsheng Liu,Jeffrey D Schmeckpeper,James E Tarara,Mark J Federspiel,Noel Caplice,Stephen J Russell,

Attenuated measles viruses (MVs) propagate selectively in human tumor cells, and phase I clinical trials are currently underway to test their oncolytic activity. A major theoretical impediment to systemic MV application is the presence of pre-existing antiviral immunity. We hypothesized that autologous MV-infected cells might be a more reliable vehicle than cell-free virions to deliver the infection to tumor cells in subjects with neutralizing titers of anti-measles antibodies. Our in vitro studies, using a dual-color fluorescent model, demonstrated efficient cell-to-cell transfer of infection via heterofusion. In contrast to infection by naked virions, heterofusion between infected cell carriers and tumor cells was more resistant to antibody neutralization. Infected monocytic, endothelial, or stimulated peripheral blood cells could deliver oncolytic MV to tumor lesions in vivo, after intravenous (i.v.) or intraperitoneal (i.p.) administration. Single or repeated i.p. injections of monocytic carriers significantly improved survival of animals bearing human ovarian cancer xenografts. Systemic or i.p. injection of MV-infected cells successfully transferred infection by heterofusion to Raji lymphomas or hepatocellular carcinoma tumors in the presence of neutralizing antibodies. These results suggest a novel strategy for systemic delivery of oncolytic virotherapy in cancer patients that can "bypass" the pre-existing humoral immunity against MV.Molecular Therapy (2007) 15, 114-122. doi:10.1038/sj.mt.6300020.

Infected cell carriers: a new strategy for systemic delivery of oncolytic measles viruses in cancer virotherapy. Publishing Authors By Initials

ID Iankov,B Blechacz,C Liu,JD Schmeckpeper,JE Tarara,MJ Federspiel,N Caplice,SJ Russell,ID Iankov,B Blechacz,C Liu,JD Schmeckpeper,JE Tarara,MJ Federspiel,N Caplice,SJ Russell,

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Infected cell carriers: a new strategy for systemic delivery of oncolytic measles viruses in cancer virotherapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular therapy : the journal of the American So

VOLUME: 15

Page Numbers: 114-22

Journal Abbreviation: Mol. Ther.

ISSN: 1525-0016

DAY: 13

MONTH: Jan

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 100890581

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AFFILIATION: 1Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota, USA.

Country: United States

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MEDLINETA: Mol Ther

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