Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models.

Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models. Research Abstract Details 

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Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models. Abstract Text:

H Sikorska,J Rousseau,C Desputeau,A Gervais,S Savoie,M A Ghaffari,L Bisson,J E van Lier,

A new mouse monoclonal antibody that recognizes alpha- and beta-heavy chains of human atrial and ventricular myosin and beta-heavy chain of human slow skeletal muscle myosin was obtained. The 125I- and 111In-labelled antibody, and its F(ab')2 and Fab fragments localize in isoproterenol induced infarcted rat heart, with the F(ab')2 fragment showing the highest uptake. Comparison with 99Tc-pyrophosphate uptake in infarcted dog heart, induced by selective obstruction of a coronary artery, suggest that the 111In-labelled F(ab')2 localizes specifically in infarcted myocardium only.

Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models. Publishing Authors By Initials

H Sikorska,J Rousseau,C Desputeau,A Gervais,S Savoie,MA Ghaffari,L Bisson,JE van Lier,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of radiation applications an

VOLUME: 17

Page Numbers: 567-84

Journal Abbreviation:

ISSN: 0883-2897

DAY: 21

MONTH: 02

YEAR: 1990

Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8611098

Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models. Information

Substance Name: imciromab pentetate

Registry Number: 138660-99-8

Grant and Affiliation Information for Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models.

AFFILIATION: Rougier Bio-Tech Ltd., Montreal, Quebec, Canada.

Country: UNITED STATES

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MEDLINETA: Int J Rad Appl Instrum B

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