Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media.

Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media. Research Abstract Details 

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Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media. Abstract Text:

J Lin,A Haruta,H Kawano,S B Ho,G L Adams,S K Juhn,Y Kim,

Mucoid otitis media (MOM) is characterized by viscous fluid, high in mucin concentration, which accumulates in the middle ear cavity. Recent studies suggest that initial infection in the middle ear cleft may be key to the development of MOM. However, factors of the initial infection attributed to the stimulation of mucin production are not clearly understood. This study demonstrated that tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine in mucoid effusion, markedly increased Muc2 mucin mRNA expression in middle ear epithelium, in a time- and dose-dependent manner. Parallel to this was a marked increase in mucin glycoprotein in middle ear fluid. Also, TNF-alpha demonstrated an autocrine and/or paracrine effect on the expression of endogenous TNF-alpha gene in the middle ear, which may contribute to the production of mucin in this study. These findings suggest that TNF-alpha plays an important role in the development of MOM by stimulating mucin metabolism.

Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media. Publishing Authors By Initials

J Lin,A Haruta,H Kawano,SB Ho,GL Adams,SK Juhn,Y Kim,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of infectious diseases

VOLUME: 182

Page Numbers: 882-7

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 17

MONTH: 08

YEAR: 2000

Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media. Information

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LANGUAGE: eng

NlmUniqueID: 413675

Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media. Information

Substance Name: Tumor Necrosis Factor-alpha

Registry Number: 0

Grant and Affiliation Information for Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media.

AFFILIATION: Otitis Media Research Center, Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA. linxx004@tc.umn.edu

Country: UNITED STATES

AGENCY: United States NIDCD

GRANT: DC03433

ACRONYM: DC

MEDLINETA: J Infect Dis

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