Induction of globin gene expression in cultured erythroleukemia cells by butyric acid.

Induction of globin gene expression in cultured erythroleukemia cells by butyric acid. Research Abstract Details 

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Induction of globin gene expression in cultured erythroleukemia cells by butyric acid. Abstract Text:

R Kameji,M Obinata,Y Natori,Y Ikawa,

Butyric acid induces erythroid differentiation of cultured Friend leukemia cells when added to the culture medium. A high level of globin messenger RNA (mRNA) was detected in Friend leukemia cells treated with butyric acid by a liquid hybridization method using radioactive DNA complementary to reticulocyte globin mRNA. The content of globin mRNA molecules induced in the cytoplasm of the butyric acid-treated Friend leukemia cells paralleled the hemoglobin content determined by the benzidine staining method. Therefore, this hemoglobin synthesis may be most reasonably explained in terms of transcriptional activation of globin genes, as previously proposed in the case of dimethylsulfoxide, another inducer of erythroid differentiation. Induced accumulation of globin mRNA in the nuclei also supports this interpretation.

Induction of globin gene expression in cultured erythroleukemia cells by butyric acid. Publishing Authors By Initials

R Kameji,M Obinata,Y Natori,Y Ikawa,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Induction of globin gene expression in cultured erythroleukemia cells by butyric acid. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 81

Page Numbers: 1901-10

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jun

YEAR: 1977

Induction of globin gene expression in cultured erythroleukemia cells by butyric acid. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Induction of globin gene expression in cultured erythroleukemia cells by butyric acid. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: drug effects

Chemical & Substance for Abstract: Induction of globin gene expression in cultured erythroleukemia cells by butyric acid. Information

Substance Name: Globins

Registry Number: 9004-22-2

Grant and Affiliation Information for Induction of globin gene expression in cultured erythroleukemia cells by butyric acid.

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Country: JAPAN

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MEDLINETA: J Biochem

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