Induction of free radicals in the cochlea by an aminoglycoside antibiotic.

Induction of free radicals in the cochlea by an aminoglycoside antibiotic. Research Abstract Details 

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Induction of free radicals in the cochlea by an aminoglycoside antibiotic. Abstract Text:

M Takayama,H Yamane,K Konishi,H Iguchi,S Shibata,K Sunami,Y Nakai,T Nakagawa,

Free radicals are known to cause damage to biological tissues. We used histochemical methods to examine the emergence of free radicals in kanamycin (KM)-treated guinea pig cochlea. As a preliminary in vitro study, the emergence of free radicals was observed in guinea pig cochlea incubated with KM. In an in vivo study, KM was placed on the guinea pig round window membrane and the emergence of free radicals was observed over time. The emergence of free radicals was observed along the luminal membrane and hair bundles of outer hair cells. The appearance and disappearance of free radicals in the cochlea coincided with the transport of KM into the inner ear. These findings suggest that the emergence of free radicals could be attributed to the administration of KM.

Induction of free radicals in the cochlea by an aminoglycoside antibiotic. Publishing Authors By Initials

M Takayama,H Yamane,K Konishi,H Iguchi,S Shibata,K Sunami,Y Nakai,T Nakagawa,

For similar ear, inner: cochlea: round window, ear research abstracts see: ear, inner: cochlea: round window, ear research

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Induction of free radicals in the cochlea by an aminoglycoside antibiotic. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 528

Page Numbers: 19-24

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1997

Induction of free radicals in the cochlea by an aminoglycoside antibiotic. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Induction of free radicals in the cochlea by an aminoglycoside antibiotic. Keywords Mesh Terms:

KEYWORDS: Round Window, Ear

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Induction of free radicals in the cochlea by an aminoglycoside antibiotic. Information

Substance Name: Kanamycin

Registry Number: 59-01-8

Grant and Affiliation Information for Induction of free radicals in the cochlea by an aminoglycoside antibiotic.

AFFILIATION: Department of Otolaryngology, Osaka City University Medical School, Japan.

Country: NORWAY

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MEDLINETA: Acta Otolaryngol Suppl

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