Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells.

Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells. Research Abstract Details 

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Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells. Abstract Text:

Yumi Miyamoto-Yamasaki,Masao Yamasaki,Hirofumi Tachibana,Koji Yamada,Yumi Miyamoto-Yamasaki,Masao Yamasaki,Hirofumi Tachibana,Koji Yamada,Yumi Miyamoto-Yamasaki,Masao Yamasaki,Hirofumi Tachibana,Koji Yamada,

The effect of the pan c-Jun N-terminal kinase (JNK) inhibitor SP600125 on the proliferation of human lung carcinoma A549 cells has been evaluated. We have shown that SP600125 completely inhibited the proliferation of A549 cells, the cycle arrest being in G2/M phase. When cells were treated with SP600125 for >12h, a cell population with DNA content of 4n to 8n was detected. Moreover, the effect of SP600125 on the expression of cell cycle related proteins was an upregulation of p53 protein accompanied by an increase in its molecular mass. Prolonged SP600125 treatment downregulated p21, Bax and Mdm2 expression, but increased the level of the cellular p53-Mdm2 complex. Taken together, we show that SP600125 could induce G2/M cell cycle arrest and endoreduplication in a p21 independent manner, and that SP600125 could also post-translationally modify p53 to modify its function. Our data show that basic JNK activity plays an important role in the progression of the cell cycle at G2/M cell phase.

Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells. Publishing Authors By Initials

Y Miyamoto-Yamasaki,M Yamasaki,H Tachibana,K Yamada,Y Miyamoto-Yamasaki,M Yamasaki,H Tachibana,K Yamada,Y Miyamoto-Yamasaki,M Yamasaki,H Tachibana,K Yamada,

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Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell biology international

VOLUME: 31

Page Numbers: 1501-6

Journal Abbreviation: Cell Biol. Int.

ISSN: 1065-6995

DAY: 10

MONTH: 08

YEAR: 2007

Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells. Information

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LANGUAGE: eng

NlmUniqueID: 9307129

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AFFILIATION: Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.

Country: England

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MEDLINETA: Cell Biol Int

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