Induction of COX-2 by acrolein in rat lung epithelial cells.

Induction of COX-2 by acrolein in rat lung epithelial cells. Research Abstract Details 

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Induction of COX-2 by acrolein in rat lung epithelial cells. Abstract Text:

Poonam Sarkar,Barbara E Hayes,

Acrolein is a highly reactive alpha, beta-unsaturated aldehyde, and a product of lipid peroxidation reactions. Acrolein is also an environmental pollutant and a key component of cigarette smoke, and has been implicated in multiple respiratory diseases. Lung tissue is a primary target for acrolein toxicity in smokers and may lead to chronic lung inflammation and lung cancer. Chronic inflammation, associated with expression of cyclooxygenase-2 (COX-2) and prostaglandins, are predisposing factors for malignancy. In this study, we investigated the induction of COX-2 by acrolein in rat lung epithelial cells and its related signaling cascade. Induction of COX-2 by acrolein was significant at 6 h post-treatment and was dependent upon NFkappaB activation. The activation of NFkappaB by acrolein was induced as a result of degradation of IkappaBalpha over the time of treatment. In addition, the upstream signaling cascade involved Raf-1/ERK activation by acrolein in the COX-2 induction and was inhibited by GW5074 (a Ras/Raf-1/ERK inhibitor), thereby providing evidence for the role of this cascade in this process. The results of these studies offer an explanation for the mechanism of COX-2 induction by acrolein in rat lung epithelial cells.

Induction of COX-2 by acrolein in rat lung epithelial cells. Publishing Authors By Initials

P Sarkar,BE Hayes,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: ras proteins research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: ras proteins research

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Induction of COX-2 by acrolein in rat lung epithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular and cellular biochemistry

VOLUME: 301

Page Numbers: 191-9

Journal Abbreviation: Mol. Cell. Biochem.

ISSN: 0300-8177

DAY: 21

MONTH: 02

YEAR: 2007

Induction of COX-2 by acrolein in rat lung epithelial cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 364456

Induction of COX-2 by acrolein in rat lung epithelial cells. Keywords Mesh Terms:

KEYWORDS: ras Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Induction of COX-2 by acrolein in rat lung epithelial cells. Information

Substance Name: ras Proteins

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for Induction of COX-2 by acrolein in rat lung epithelial cells.

AFFILIATION: College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.

Country: Netherlands

AGENCY: United States NCRR

GRANT: RR03045-18

ACRONYM: RR

MEDLINETA: Mol Cell Biochem

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