Induction of autoimmunity after allotransplantation.

Induction of autoimmunity after allotransplantation. Research Abstract Details 

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Induction of autoimmunity after allotransplantation. Abstract Text:

Gilles Benichou,Alessandro Alessandrini,Rachida-Sihem Charrad,David S Wilkes,

Our studies show that activated autoreactive inflammatory T cells specific and autoantibodies to collagen (V) and cardiac myosin are consistently detected after lung and heart transplantation, respectively. Clonal expansion of these T cells occurs only after an alloresponse, but once activated they can induce on their own rejection of allogeneic and even syngeneic transplants. Indirect rather than indirect alloresponse triggers autoimmunity after transplantation presumably via antigen mimicry between autoantigen peptides and donor MHC peptides. Also, it is plausible that inflammation and tissue damage associated with initial alloresponse to donor MHC antigens causes the release of formerly sequestered autoantigens. This may result in the presentation of some cryptic self-determinants thereby triggering an autoimmune process at the site of the graft. Finally, tolerance induction to cardiac myosin and collagen (V) results in long-term survival and reduced pathogenesis of heart and lung allografts, respectively. This suggests that, after transplantation, the inflammatory alloresponse to donor MHC triggers a cascade of events including autoimmunity to tissue antigens, a phenomenon that is essential to the actual rejection.

Induction of autoimmunity after allotransplantation. Publishing Authors By Initials

G Benichou,A Alessandrini,RS Charrad,DS Wilkes,

For similar surgical procedures, operative: transplantation: transplantation, homologous research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous research

PUBMED ID PMID:

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Induction of autoimmunity after allotransplantation. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 12

Page Numbers: 4362-9

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 05

YEAR: 2007

Induction of autoimmunity after allotransplantation. Information

Number of References: 57

LANGUAGE: eng

NlmUniqueID: 9709506

Induction of autoimmunity after allotransplantation. Keywords Mesh Terms:

KEYWORDS: Transplantation, Homologous

MESH TERMS: immunology

Chemical & Substance for Abstract: Induction of autoimmunity after allotransplantation. Information

Substance Name: Autoantigens

Registry Number: 0

Grant and Affiliation Information for Induction of autoimmunity after allotransplantation.

AFFILIATION: Department of Surgery, Transplantation Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. gbenichou@partners.org

Country: United States

AGENCY: United States NHLBI

GRANT: R01HL60797

ACRONYM: HL

MEDLINETA: Front Biosci

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