Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells.

Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells. Abstract Text:

Kang Beom Kwon,Eun Kyung Kim,Mi Jeong Han,Byung Cheul Shin,Yong Kweon Park,Kang San Kim,Young Rae Lee,Jin Woo Park,Byung Hyun Park,Do Gon Ryu,

Radix Paeoniae Alba has been used as a constituent of herbal medicine prescriptions for the treatment of inflammation, cancer, and other diseases. The aim of this study was to investigate the mechanism of Radix Paeoniae Alba extract (RPAE)-induced apoptosis in HL-60 leukemic cells. We observed that RPAE induced apoptotic changes in a dose-dependent manner, which was confirmed by DNA fragmentation and poly-(ADP-ribose) polymerase (PARP) cleavage. We also found release of cytochrome c from mitochondria to the cytosol in RPAE-treated HL-60 cells. The caspases, caspase-9 and -3, but not caspase-8, were found to be activated in response to RPAE treatment, and the caspase-3 inhibitor, Ac-DEVD-CHO, and the caspase-9 inhibitor, z-LEHD-FMK, but not the caspase-8 inhibitor, z-IETD-FMK, attenuated RPAE-induced DNA fragmentation and PARP cleavage. These results suggest that RPAE-induced apoptosis is stimulated by the release of cytochrome c to the cytosol, by procaspase-9 processing, and via a caspase-3 dependent mechanism.

Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells. Publishing Authors By Initials

KB Kwon,EK Kim,MJ Han,BC Shin,YK Park,KS Kim,YR Lee,JW Park,BH Park,do G Ryu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biological & pharmaceutical bulletin

VOLUME: 29

Page Numbers: 1082-6

Journal Abbreviation: Biol. Pharm. Bull.

ISSN: 0918-6158

DAY: 6

MONTH: Jun

YEAR: 2006

Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9311984

Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells.

AFFILIATION: Rehabilitation, School of Oriental Medicine, Wonkwang University.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biol Pharm Bull

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells Related Publications

• A case of spontaneous rupture perforation of leiomyosarcoma in the urachus of a young boy.
• A highly E-stereoselective approach to beta-iodo Morita-Baylis-Hillman esters: synthesis of secokotomolide A.
• Asymmetric synthesis of (+)-cis-nemorensic acid from a chiral Diels-Alder adduct of 2,5-dimethylfuran.
• Bilateral adrenal myelolipoma associated with hyperaldosteronism: report of a case and review of the literature.
• Changes of maxillary sinus volume and bony thickness of the paranasal sinuses in longstanding pediatric chronic rhinosinusitis.
• Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells.
• Effects of a breastfeeding empowerment programme on Korean breastfeeding mothers: A quasi-experimental study.
• Focal organizing pneumonia on surgical lung biopsy: causes, clinicoradiologic features, and outcomes.
• Follicular bronchiolitis in surgical lung biopsies: Clinical implications in 12 patients.
• Hemoperitoneum Caused by Hepatic Necrosis and Rupture Following a Snakebite: a Case Report with Rare CT Findings and Successful Embolization.
• Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells.
• Low temperature synthesis of colloidal CdSe quantum dots.
• New fermentation technique for complete digestion of soybean protein.
• Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice.
• Pilomatricoma: diagnostic pitfalls in PET/CT and fine-needle aspiration biopsy.
• Reduction of interpore distance of anodized aluminum oxide nano pattern by mixed H3PO4:H2SO4 electrolyte.
• Right-handers' reaching in contralateral hemispace: a kinematic observation.
• Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response.
• Should we treat surgically in catamenial haemoptysis?
• Should we treat surgically in catamenial haemoptysis?
• Survivin as a prognostic factor for osteosarcoma patients.
• Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.
• The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice.
• Topological delocalization of two-dimensional massless Dirac fermions.
• Trichomonas vaginalis: Reactive oxygen species mediates caspase-3 dependent apoptosis of human neutrophils.
• [A prospective study comparing the efficacy of early administration of terlipressin and somatostatin for the control of acute variceal bleeding in patients with cirrhosis]
• [Analysis of the factors that affect the diagnostic yield of capsule endoscopy in patients with obscure gastrointestinal bleeding]
• [Comparison of CTP, MELD, and MELD-Na scores for predicting short term mortality in patients with liver cirrhosis]
• [Current status of costs and utilizations of hospital based home health nursing care in Korea]
• [Levels of the consciousness of activities among health promotion volunteers. Comparison by years of volunteer's experience]