[Induction of anti-tumor immunity by HSP gp96-peptide complexes]

[Induction of anti-tumor immunity by HSP gp96-peptide complexes] Research Abstract Details 

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[Induction of anti-tumor immunity by HSP gp96-peptide complexes] Abstract Text:

Tian-Yi Zhang,Ji-Xiao Niu,Lin Lin,Xiao-Chun Huang,Jun-Yi Gu,

AIM: To immunize the mice with gp96-peptide complexes extracted and purified from different kinds of malignant tumor cells and to observe anti-tumor immunity induced by the complexes. METHODS: HSP gp96-peptide complexes were extracted and purified from different kinds of malignant tumor cells. Mice were immunized subcutaneously with the complexes from different sources at different doses. Then the mice were challenged with 2 x 10(5) tumor cells on the seventh day after the last immunization. Tumor incidence, weight and histology were observed and compared with those of control group. At the meantime, cytotoxicity activity and nitric oxide production of mouse peritoneal macrophages were detected in vitro after being stimulated with gp96-peptide complexes. RESULTS: The SDS-PAGE and Western blot showed that gp96-peptide complexes were purified successfully. The anti-tumor immunity was correlated with the dose of the complex and the immunized mice could resist the challenge of homogeneous tumor cells. NO secreted from the peritoneal macrophages stimulated with the complex was significantly higher than that of control group and the tumoricidal activity of the macrophages in vitro was markedly promoted by the complex. CONCLUSION: Mice immunized with appropriate dose of gp96-peptide complexes from H22 tumor cells can resist the challenge of syngeneic tumor cells. NO secreted by macrophages stimulated with the complex might play a key role in the anti-tumor immunity.

[Induction of anti-tumor immunity by HSP gp96-peptide complexes] Publishing Authors By Initials

TY Zhang,JX Niu,L Lin,XC Huang,JY Gu,

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[Induction of anti-tumor immunity by HSP gp96-peptide complexes] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese jour

VOLUME: 21

Page Numbers: 17-20

Journal Abbreviation: Xi Bao Yu Fen Zi Mian Yi Xue Z

ISSN: 1007-8738

DAY: 4

MONTH: Jan

YEAR: 2005

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LANGUAGE: chi

NlmUniqueID: 101139110

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Grant and Affiliation Information for [Induction of anti-tumor immunity by HSP gp96-peptide complexes]

AFFILIATION: Analytical Cytology Lab., Nantong Medical College, Nantong 226001, China.

Country: China

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MEDLINETA: Xi Bao Yu Fen Zi Mian Yi Xue Z

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