Induction of a program gene expression during osteoblast differentiation with strontium ranelate.

Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Research Abstract Details 

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Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Abstract Text:

Ling-Ling Zhu,Samir Zaidi,Yuanzhen Peng,Hang Zhou,Baljit S Moonga,Alexia Blesius,Isabelle Dupin-Roger,Mone Zaidi,Li Sun,

Strontium ranelate, a new agent for the treatment of osteoporosis, has been shown stimulate bone formation in various experimental models. This study examines the effect of strontium ranelate on gene expression in osteoblasts, as well as the formation of mineralized (von Kossa-positive) colony-forming unit-osteoblasts (CFU-obs). Bone marrow-derived stromal cells cultured for 21 days under differentiating conditions, when exposed to strontium ranelate, displayed a significant time- and concentration-dependent increase in the expression of the master gene, Runx2, as well as bone sialoprotein (BSP), but interestingly without effects on osteocalcin. This was associated with a significant increase in the formation of CFU-obs at day 21 of culture. In U-33 pre-osteoblastic cells, strontium ranelate significantly enhanced the expression of Runx2 and osteocalcin, but not BSP. Late, more mature osteoblastic OB-6 cells showed significant elevations in BSP and osteocalcin, but with only minimal effects on Runx2. In conclusion, strontium ranelate stimulates osteoblast differentiation, but the induction of the program of gene expression appears to be cell type-specific. The increased osteoblastic differentiation is the likely basis underlying the therapeutic bone-forming actions of strontium ranelate.

Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Publishing Authors By Initials

LL Zhu,S Zaidi,Y Peng,H Zhou,BS Moonga,A Blesius,I Dupin-Roger,M Zaidi,L Sun,

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Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biochemical and biophysical research communication

VOLUME: 355

Page Numbers: 307-11

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 30

MONTH: 01

YEAR: 2007

Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Information

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LANGUAGE: eng

NlmUniqueID: 372516

Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Keywords Mesh Terms:

KEYWORDS: Thiophenes

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Induction of a program gene expression during osteoblast differentiation with strontium ranelate. Information

Substance Name: strontium ranelate

Registry Number: 0

Grant and Affiliation Information for Induction of a program gene expression during osteoblast differentiation with strontium ranelate.

AFFILIATION: Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

Country: United States

AGENCY: United States NIA

GRANT: R01 AG 14197

ACRONYM: AG

MEDLINETA: Biochem Biophys Res Commun

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