Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B.

Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B. Research Abstract Details 

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Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B. Abstract Text:

Amos B Smith, ,Akin H Davulcu,Young Shin Cho,Kazuyuki Ohmoto,

A second-generation strategy for construction of (+)-nodulisporic acids A and B based on the development of a new, effective modular indole synthesis exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic is disclosed. This strategy evolved due to the considerable acid instability of the C(24) hydroxyl group observed in several advanced intermediates during our first-generation approach.

Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B. Publishing Authors By Initials

AB Smith,L ,AH Davulcu,YS Cho,K Ohmoto,

For similar natural sciences: physics: thermodynamics research abstracts see: natural sciences: physics: thermodynamics research

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Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of organic chemistry

VOLUME: 72

Page Numbers: 4611-20

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 19

MONTH: 05

YEAR: 2007

Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B. Information

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LANGUAGE: eng

NlmUniqueID: 2985193

Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B. Keywords Mesh Terms:

KEYWORDS: Thermodynamics

MESH TERMS: chemistry

Chemical & Substance for Abstract: Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B. Information

Substance Name: aniline

Registry Number: 62-53-3

Grant and Affiliation Information for Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B.

AFFILIATION: Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM-29028

ACRONYM: GM

MEDLINETA: J Org Chem

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