Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals.

Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals. Research Abstract Details 

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Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals. Abstract Text:

Claudia Istrate,Jorma Hinkula,Lennart ,Lennart Svensson,Claudia Istrate,Jorma Hinkula,Lennart ,Lennart Svensson,

While IgA is proposed to be essential to control rotavirus disease, no information is available how IgA deficient individuals modulate rotavirus disease and immune responses. In this study it was shown that patients (n = 62) with selective IgA deficiency (IgA-D) (<0.05 g/L) resolve rotavirus disease and show higher total IgG and IgG1 subclass antibody titers to rotavirus than IgA proficient individuals (n = 62) (geometric mean titer, GMT) 18,101 vs. 4,000 (P < 0.005); 8,463 vs. 1691, (P < 0.005). It is concluded that IgA is not essential for resolving rotavirus disease in humans. J. Med. Virol. 80:531-535, 2008. (c) 2008 Wiley-Liss, Inc.

Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals. Publishing Authors By Initials

C Istrate,J Hinkula,L ,L Svensson,C Istrate,J Hinkula,L ,L Svensson,

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Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of medical virology

VOLUME: 80

Page Numbers: 531-5

Journal Abbreviation: J. Med. Virol.

ISSN: 0146-6615

DAY: 24

MONTH: Mar

YEAR: 2008

Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals. Information

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LANGUAGE: eng

NlmUniqueID: 7705876

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AFFILIATION: Instituto de Biologia Experimental e Tecnologica and Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal.

Country: United States

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MEDLINETA: J Med Virol

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