Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments.

Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments. Research Abstract Details 

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Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments. Abstract Text:

Lisa M Thornton,Barbara L Andersen,Timothy R Crespin,William E Carson,

Research connects stressful events with altered immune regulation, but the role of subjective stress is uncertain. Using a longitudinal design, we provide a statistically powerful test of the relationship between subjective stress (perceived stress, emotional distress) and immunity (T cell blastogenesis, natural killer cell cytotoxicity, [NKCC]) as individuals adjust to a severe stressor, a cancer diagnosis and its treatments. Women with regional breast cancer (N=113) were assessed at diagnosis/surgery and reassessed 4, 8, 12, and 18 months later. Latent growth curve analysis tested two hypotheses: (1) initial levels of subjective stress will correlate inversely with initial levels of immunity, and (2) rate of change in subjective stress will correlate inversely with rate of change in immunity. As predicted by Hypothesis 1, participants with high initial subjective stress showed poor initial blastogenesis. As predicted by Hypothesis 2, participants exhibiting an early, rapid decline in subjective stress also showed rapid improvement in NKCC. Follow-up analyses revealed perceived stress to be strongly related to immune function, while emotional distress was not. This is the first study to investigate trajectories in stress and immunity during recovery from a major stressor. Results imply that NK and T cells are sensitive to different aspects of the stress response. While T cell blastogenesis correlated with initial (peak) subjective stress, NKCC correlated with change (improvement) in subjective stress. These data highlight the importance of subjective stress, particularly stress appraisals, in the immune response to a major stressor.

Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments. Publishing Authors By Initials

LM Thornton,BL Andersen,TR Crespin,WE Carson,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Brain, behavior, and immunity

VOLUME: 21

Page Numbers: 185-94

Journal Abbreviation: Brain Behav. Immun.

ISSN: 0889-1591

DAY: 5

MONTH: 09

YEAR: 2006

Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments. Information

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LANGUAGE: eng

NlmUniqueID: 8800478

Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: immunology

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Grant and Affiliation Information for Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments.

AFFILIATION: Department of Psychology, The Ohio State University, 159 Psychology Building, 1835 Neil Avenue, Columbus, Ohio 43210, USA. thornton.84@osu.edu

Country: United States

AGENCY: United States NIMH

GRANT: R01 MH51487

ACRONYM: MH

MEDLINETA: Brain Behav Immun

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