Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice.

Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Research Abstract Details 

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Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Abstract Text:

Maureen V Martin,Hongxin Dong,Dana Vallera,David Lee,Lu Lu,Robert W Williams,Glenn D Rosen,James M Cheverud,John G Csernansky,

Anatomical and functional studies support segregation of the hippocampus into ventral and dorsal components along its septotemporal axis. However, it is unknown whether the development of these two components of the hippocampus is influenced by common or separate genetic factors. In this study, we used recombinant inbred strains of mice to determine whether the same or different quantitative trait loci (QTL) influence ventral and dorsal hippocampal volume. Using two sets of strains of recombinant inbred mice (BXD and AXB/BXA), we identified separate QTLs for ventral and dorsal hippocampal volume. In BXD mice, suggestive QTLs for ventral hippocampus were identified on chromosomes 2, 8 and 13, and a significant QTL for dorsal hippocampal volume was identified on chromosome 15. There was also a suggestive QTL for dorsal hippocampal volume on chromosome 13. In AXB/BXA mice, there were no significant or suggestive QTLs for ventral hippocampal volume, but a significant QTL for dorsal hippocampus was identified on chromosome 5. These findings suggest that the development of the ventral and dorsal components of the hippocampus is influenced by separate genetic loci.

Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Publishing Authors By Initials

MV Martin,H Dong,D Vallera,D Lee,L Lu,RW Williams,GD Rosen,JM Cheverud,JG Csernansky,

For similar biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research

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Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genes, brain, and behavior

VOLUME: 5

Page Numbers: 614-23

Journal Abbreviation: Genes Brain Behav.

ISSN: 1601-1848

DAY: 3

MONTH: Nov

YEAR: 2006

Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Information

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LANGUAGE: eng

NlmUniqueID: 101129617

Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Keywords Mesh Terms:

KEYWORDS: Species Specificity

MESH TERMS: genetics

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Grant and Affiliation Information for Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice.

AFFILIATION: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

Country: England

AGENCY: United States NIAAA

GRANT: U24AA13513

ACRONYM: AA

MEDLINETA: Genes Brain Behav

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