Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats.

Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats. Research Abstract Details 

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Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats. Abstract Text:

Natalia Sinitskaya,Sylviane Gourmelen,Carole Schuster-Klein, Guardiola-Lemaitre,Paul ,Etienne Challet,Natalia Sinitskaya,Sylviane Gourmelen,Carole Schuster-Klein, Guardiola-Lemaitre,Paul ,Etienne Challet,Natalia Sinitskaya,Sylviane Gourmelen,Carole Schuster-Klein, Guardiola-Lemaitre,Paul ,Etienne Challet,

Metabolic disorders induced by high-fat feeding in rodents evoke some, if not all, of the features of human metabolic syndrome. The occurrence and severity of metabolic disorders, however, varies according to rodent species, and even strain, as well as the diet. Therefore, in the present study, we investigated the long-term obesogenic and diabetogenic effects of three high-fat diets differing by their fat/carbohydrate ratios. Sprague-Dawley rats were fed a control high-carbohydrate and low-fat diet [HCD; 3:16:6 ratio of fat/carbohydrate/protein; 15.48 kJ/g (3.7 kcal/g)], a high-fat and medium-carbohydrate diet [HFD1; 53:30:17 ratio of fat/carbohydrate/protein; 19.66 kJ/g (4.7 kcal/g)], a very-high-fat and low-carbohydrate diet [HFD2; 67:9:24 ratio of fat/carbohydrate/protein; 21.76 kJ/g (5.2 kcal/g)] or a very-high-fat and carbohydrate-free diet [HFD3; 75:0:25 ratio of fat/carbohydrate/protein; 24.69 kJ/g (5.9 kcal/g)] for 10 weeks. Compared with the control diet (HCD), rats fed with high-fat combined with more (HFD1) or less (HFD2) carbohydrate exhibited higher BMI (body mass index; +13 and +10% respectively; P<0.05) and abdominal fat (+70% in both HFD1 and HFD2; P<0.05), higher plasma leptin (+130 and +135% respectively; P<0.05), lower plasma adiponectin levels (-23 and -30% respectively; P<0.05) and impaired glucose tolerance. Only the HFD1 group had insulin resistance. By contrast, a very-high-fat diet devoid of carbohydrate (HFD3) led to impaired glucose tolerance, insulin resistance and hypoadiponectinaemia (-50%; P<0.05), whereas BMI, adiposity and plasma leptin did not differ from respective values in animals fed the control diet. We conclude that increasing the fat-to-carbohydrate ratio to the uppermost (i.e. carbohydrate-free) in a high-fat diet prevents the development of obesity, but not the prediabetic state (i.e. altered glucose tolerance and insulin sensitivity).

Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats. Publishing Authors By Initials

N Sinitskaya,S Gourmelen,C Schuster-Klein,B Guardiola-Lemaitre,P ,E Challet,N Sinitskaya,S Gourmelen,C Schuster-Klein,B Guardiola-Lemaitre,P ,E Challet,N Sinitskaya,S Gourmelen,C Schuster-Klein,B Guardiola-Lemaitre,P ,E Challet,

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Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical science (London, England : 1979)

VOLUME: 113

Page Numbers: 417-25

Journal Abbreviation: Clin. Sci.

ISSN: 1470-8736

DAY: 11

MONTH: Nov

YEAR: 2007

Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats. Information

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LANGUAGE: eng

NlmUniqueID: 7905731

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AFFILIATION: Département de Neurobiologie des Rythmes, Institut de Neurosciences Cellulaires et Intégratives, CNRS, Université Louis Pasteur, 5 rue Blaise pascal, 67084 Strasbourg, France.

Country: England

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MEDLINETA: Clin Sci (Lond)

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