[Increasing activity of the intestinal mucosal mast cells in rats with multiple organ failure]

[Increasing activity of the intestinal mucosal mast cells in rats with multiple organ failure] Research Abstract Details 

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[Increasing activity of the intestinal mucosal mast cells in rats with multiple organ failure] Abstract Text:

Cheng-wei Tang,Cheng Lan,

OBJECTIVE: To investigate changes in activities of the intestinal mucosal mast cells (IMMC) in multiple organ failure(MOF). METHODS: MOF model in rat was established by injection of zymosan. The concentrations of histamine and tumor necrosis factor-alpha(TNF-alpha) in plasma and intestine tissue were examined. Both the function and the pathological alterations of vital organs including intestine, liver, kidneys and lungs were measured or visualized under light microscope. Furthermore, the ultrastructure of the IMMC was observed with a transmission electronic microscope. RESULTS: The injection of zymosan resulted in obvious inflammatory response in multiple organs, as well as significantly impaired function. Compared with the normal rats, the histamine levels in the intestinal tissue from rats with MOF remarkably decreased [(11.63+/-1.97) ng/g vs.(8.67+/-1.16) ng/g], while the plasma histamine levels did not show any significant changes. For TNF-alpha, apparently increasing levels in both intestinal tissue and plasma were observed in MOF rats. Meanwhile, the increasing number and degranulation of IMMC during MOF were impressive. CONCLUSION: The histamine and TNF-alpha released from activated IMMC may play an important role in the development of MOF.

[Increasing activity of the intestinal mucosal mast cells in rats with multiple organ failure] Publishing Authors By Initials

CW Tang,C Lan,

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[Increasing activity of the intestinal mucosal mast cells in rats with multiple organ failure] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese cr

VOLUME: 15

Page Numbers: 7-10

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ISSN: 1003-0603

DAY: 10

MONTH: Jan

YEAR: 2003

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LANGUAGE: chi

NlmUniqueID: 9887521

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Grant and Affiliation Information for [Increasing activity of the intestinal mucosal mast cells in rats with multiple organ failure]

AFFILIATION: Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Country: China

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MEDLINETA: Zhongguo Wei Zhong Bing Ji Jiu

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