Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice.

Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice. Abstract Text:

Scott E Bowen,

RATIONALE: Toluene, an abused solvent, shares behavioral and pharmacological effects with abused depressant drugs. These effects include ethanol- and pentobarbital-like discriminative stimulus effects. There is also emerging evidence that this abused inhalant may share stimulus effects with abused central nervous system (CNS) stimulants. OBJECTIVE: To further explore the discriminative stimulus effects of one abused inhalant, this experiment evaluated the amphetamine-like discriminative stimulus effects of toluene. MATERIALS AND METHODS: Mice were trained to discriminate between d-amphetamine (1.0 mg/kg) and saline in a two-lever drug discrimination procedure in which responding was under the control of a fixed-ratio 15 schedule. Mice were tested after 10-min inhalation exposures to air or toluene (500-6,000 ppm) and stimulus generalization was examined at 0, 15, 30, 45, 60, and 75 min post-exposure. RESULTS: Concentration-related increases in amphetamine-lever responding were observed for amphetamine doses >0.56 mg/kg with full substitution occurring immediately after testing for 1.0 and 1.78 mg/kg. Partial amphetamine-lever responding was observed for all concentrations of toluene across the 75-min post-exposure test trials. Response rates that had decreased immediately after all toluene exposures recovered within 15-min post exposure. CONCLUSION: This partial substitution of toluene for amphetamine suggests that studies of the effects of abused solvents on brain dopaminergic systems need to be included in the study of possible CNS mechanisms.

Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice. Publishing Authors By Initials

SE Bowen,

For similar organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: benzene derivatives: toluene research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: benzene derivatives: toluene research

PUBMED ID PMID:

MEDLINE DATE:

Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychopharmacology

VOLUME: 186

Page Numbers: 517-24

Journal Abbreviation: Psychopharmacology (Berl.)

ISSN: 0033-3158

DAY: 7

MONTH: 04

YEAR: 2006

Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608025

Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice. Keywords Mesh Terms:

KEYWORDS: Toluene

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice. Information

Substance Name: Amphetamine

Registry Number: 300-62-9

Grant and Affiliation Information for Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice.

AFFILIATION: Department of Psychology, Wayne State University, 5057 Woodward, Detroit, MI 48202, USA. Scott.Bowen@wayne.edu

Country: Germany

AGENCY: United States NIDA

GRANT: R01 DA015095

ACRONYM: DA

MEDLINETA: Psychopharmacology (Berl)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice Related Publications

• Acute onset left hemiparesis and facial droop in a 37 year old soccer player: 1123: june 1 3:15 PM - 3:35 PM.
• C1584 in von Willebrand factor is necessary for enhanced proteolysis by ADAMTS13 in vitro.
• Chain of custody as an organizing framework in seafood risk reduction.
• Complex palliative care and transition: a case review.
• Decontaminable surfaces for millicurie-level laboratories.
• Determination of cell colony formation in a high-content screening assay.
• Duplications involving int22h-1 of the factor VIII gene: a cause for concern in genetic testing for hemophilia A?
• Dynamics of passive immunity to West Nile virus in domestic chickens (Gallus gallus domesticus).
• Electron-cytochemical localization of acid phosphatase activity in the digestive caeca of the desert locust.
• Failure to induce an antiviral state in preimplantation bovine embryos treated with interferon.
• Health impact assessments in London: assessing the London Mayoral strategies.
• Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice.
• MR angiography versus CT angiography in the evaluation of neurovascular disease.
• Methods and normal values for echocardiography in adult dairy cattle.
• Photoelectron spectroscopy of hydrated adenine anions.
• Predictors of self-referral into a cancer genetics registry.
• Raloxifene and selective cell cycle specific agents: a case for the inclusion of raloxifene in current breast cancer treatment therapies.
• Results of a randomized study of telephone versus in-person breast cancer risk counseling.
• Salivary glucosyltransferase B as a possible marker for caries activity.
• Self-rated breast cancer risk among women reporting a first-degree family history of breast cancer on office screening questionnaires in routine medical care: the role of physician-delivered risk feedback.
• Sequence-dependent administration of raloxifene and 5-fluorouracil/pemetrexed protects against pemetrexed cytotoxicity in human bone marrow.
• Sequential combination chemotherapy in human breast cancer: a basis for increased antineoplastic activity and bone marrow protection.
• Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis.
• The cancer worry chart: a single-item screening measure of worry about developing breast cancer.
• The correction of leg-length discrepancy after treatment in developmental dysplasia of the hip by using a percutaneous epiphysiodesis.
• The effects of methyltestosteone on reproductive function in male greyhounds.
• The effects of prostalene and alfaprostol as uterine myotonics, and the effect on postpartum pregnancy rate in the mare following daily treatment with prostalene.
• The impact of HIV-related interventions on HIV risk behavior in a community sample of African American crack cocaine users.
• The protection against trimetrexate cytotoxicity in human bone marrow by sequence-dependent administration of raloxifene, 5-fluorouracil/trimetrexate.
• Use of the statistical properties of the wavelet-transform coefficients for optimization of integration time in Fourier transform spectrometry.