Increased temporal and prefrontal activity in response to semantic associations in schizophrenia.

Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Abstract Text:

Gina R Kuperberg,Thilo Deckersbach,Daphne J Holt,Donald Goff,W Caroline West,

CONTEXT: Loosening of associations has long been considered a core feature of schizophrenia, but its neural correlate remains poorly understood. OBJECTIVE: To test the hypothesis that, in comparison with healthy control subjects, patients with schizophrenia show increased neural activity within inferior prefrontal and temporal cortices in response to directly and indirectly semantically related (relative to unrelated) words. DESIGN: A functional neuroimaging study using a semantic priming paradigm. SETTING: Lindemann Mental Health Center, Boston, Mass. PARTICIPANTS: Seventeen right-handed medicated outpatients with chronic schizophrenia and 15 healthy volunteers, matched for age and parental socioeconomic status. INTERVENTIONS: Functional magnetic resonance imaging as participants viewed directly related, indirectly related, and unrelated word pairs and performed a lexical decision task. MAIN OUTCOME MEASURES: Event-related functional magnetic resonance imaging measures of blood oxygenation level-dependent activity (1) within a priori temporal and prefrontal anatomic regions of interest and (2) at all voxels across the cortex. RESULTS: Patients and controls showed no behavioral differences in priming but opposite patterns of hemodynamic modulation in response to directly related (relative to unrelated) word pairs primarily within inferior prefrontal cortices, and to indirectly related (relative to unrelated) word pairs primarily within temporal cortices. Whereas controls showed the expected decreases in activity in response to semantic relationships (hemodynamic response suppression), patients showed inappropriate increases in response to semantic relationships (hemodynamic response enhancement) in many of the same regions. Moreover, hemodynamic response enhancement within the temporal fusiform cortices to indirectly related (relative to unrelated) word pairs predicted positive thought disorder. CONCLUSION: Medicated patients with chronic schizophrenia, particularly those with positive thought disorder, show inappropriate increases in activity within inferior prefrontal and temporal cortices in response to semantic associations.

Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Publishing Authors By Initials

GR Kuperberg,T Deckersbach,DJ Holt,D Goff,WC West,

For similar psychological phenomena and processes: mental processes: learning: verbal learning research abstracts see: psychological phenomena and processes: mental processes: learning: verbal learning research

PUBMED ID PMID:

MEDLINE DATE:

Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of general psychiatry

VOLUME: 64

Page Numbers: 138-51

Journal Abbreviation: Arch. Gen. Psychiatry

ISSN: 0003-990X

DAY: 3

MONTH: Feb

YEAR: 2007

Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372435

Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Keywords Mesh Terms:

KEYWORDS: Verbal Learning

MESH TERMS: physiology

Chemical & Substance for Abstract: Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Increased temporal and prefrontal activity in response to semantic associations in schizophrenia.

AFFILIATION: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA. kuperber@nmr.mgh.harvard.edu

Country: United States

AGENCY: United States NIMH

GRANT: R01 MH071635

ACRONYM: MH

MEDLINETA: Arch Gen Psychiatry

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Increased temporal and prefrontal activity in response to semantic associations in schizophrenia Related Publications

• A prospective, population-based study of the role of visual impairment in motor vehicle crashes among older drivers: the SEE study.
• A quantitative, theoretical framework for understanding mammalian sleep.
• American society of transplantation symposium on B cells in transplantation: harnessing humoral immunity from rodent models to clinical practice.
• Azithromycin for control of trachoma.
• Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies.
• Causal inference for non-mortality outcomes in the presence of death.
• Changes in activity of the striatum during formation of a motor habit.
• Characterization of DNA-binding specificity and analysis of binding sites of the Pseudomonas aeruginosa global regulator, Vfr, a homologue of the Escherichia coli cAMP receptor protein.
• Defining the limits of conscientious objection in health care.
• Dopamine D2 receptor-dependent modulation of striatal NO synthase activity.
• Dynamic measures of visual function and their relationship to self-report of visual functioning.
• Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells.
• Identifying factors which maximise the lambing performance of hoggets: a cross sectional study.
• Increased temporal and prefrontal activity in response to semantic associations in schizophrenia.
• Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle.
• Lung cancer incidence in never smokers.
• Mechanism of DNA damage by cadmium and interplay of antioxidant enzymes and agents.
• Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH.
• Morphometry of the extremely thin pulmonary blood-gas barrier in the chicken lung.
• On use of the multistage dose-response model for assessing laboratory animal carcinogenicity.
• Performance of lactating dairy cows fed whole cottonseed coated with gelatinized starch plus urea or yeast culture.
• Peritoneal dialysis: a primary care perspective.
• Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration.
• Radiosensitivity, Radiogenomics & RAPPER.
• Scaling of number, size, and metabolic rate of cells with body size in mammals.
• Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.
• The application of self-efficacy principles to audiologic rehabilitation: a tutorial.
• The prevalence of open-angle glaucoma among blacks and whites 73 years and older: the Salisbury Eye Evaluation Glaucoma Study.
• Variation in hospital admission for AMI unlikely to be attributable to smoking legislation.
• Young people who self-harm.