Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development.

Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development. Abstract Text:

Mario ,Daniele Versari,Dallit Mannheim,Erik L Ritman,Lilach O Lerman,Amir Lerman,

OBJECTIVE: Vasa vasorum (VV) neovascularization is associated with advanced and ruptured atherosclerotic lesions that occur predominantly within the proximal third of the LAD. To investigate further the possible role of VV spatial distribution in determining this predominantly proximal location of complex lesions we analyzed the changes in VV spatial densities along the LAD in early atherosclerosis. METHODS AND RESULTS: Three-month-old, female domestic pigs were placed on normal (N; n=6) or high-cholesterol (HC; n=6) diet for 3 months. VV count, vascular-area-fraction (Sigma vasa vasorum areas/mm(2) vessel wall area, i.e., flow capacity), and the endothelial-surface-fraction (Sigma vasa vasorum endothelial surfaces/mm(3) vessel wall volume) were calculated in three equal thirds of the coronary artery from microcomputed-tomography images. In N animals, the proximal thirds tended to have a higher vascular-area-fraction (mean+/-S.D., 1.4+/-0.6 versus 0.9+/-0.3 and 0.9+/-0.2%; P=0.1) and endothelial-surface-fraction (0.72+/-0.29 versus 0.59+/-0.22 and 0.53+/-0.20 mm(2)/mm(3); NS) than the mid and distal thirds with significantly higher VV counts (26+/-12, 15+/-8, 8+/-5, P=0.01). In HC animals, we observed significant VV neovascularization (3.3+/-1.2 n/mm(2) versus 6.8+/-1.9 n/mm(2), P<0.01), with significantly higher VV counts (24+/-3 and 14+/-3 versus 6+/-4; P<0.001) as well as higher vascular-area- (1.4+/-0.2 and 1.4+/-0.2% versus 0.8+/-0.2%; P<0.001) and endothelial-surface-fractions (0.88+/-0.14 and 0.90+/-0.12 mm(2)/mm(3) versus 0.56+/-0.14 mm(2)/mm(3); P=0.001) within the proximal and middle thirds compared to the distal third. CONCLUSIONS: VV neovascularization in early atherosclerosis leads to a proximally accentuated increase in flow-capacity and endothelial-exchange-surface, which may favour the predominant development of vulnerable atherosclerotic plaques in proximal portions of the LAD.

Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development. Publishing Authors By Initials

M ,D Versari,D Mannheim,EL Ritman,LO Lerman,A Lerman,

For similar cardiovascular system: blood vessels: vasa vasorum research abstracts see: cardiovascular system: blood vessels: vasa vasorum research

PUBMED ID PMID:

MEDLINE DATE:

Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Atherosclerosis

VOLUME: 192

Page Numbers: 246-52

Journal Abbreviation: Atherosclerosis

ISSN: 0021-9150

DAY: 21

MONTH: 08

YEAR: 2006

Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 242543

Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development. Keywords Mesh Terms:

KEYWORDS: Vasa Vasorum

MESH TERMS: radiography

Chemical & Substance for Abstract: Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development.

AFFILIATION: Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, United States.

Country: Ireland

AGENCY: United States NHLBI

GRANT: HL69840

ACRONYM: HL

MEDLINETA: Atherosclerosis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development Related Publications

• Adenosine-insensitive focal atrial tachycardia: evidence for de novo micro-re-entry in the human atrium.
• Antioxidant vitamins induce angiogenesis in the normal pig kidney.
• Assessment of myocardial microvascular function: new opportunities in fast computed tomography.
• Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: comparison with electron-beam CT.
• Association of OPRM1 A118G variant with the relative reinforcing value of nicotine.
• CREB1 haplotypes and the relative reinforcing value of nicotine.
• Can pharmacogenetics help smokers quit?
• Clinical and electrophysiological spectrum of idiopathic ventricular outflow tract arrhythmias.
• Comparison of mathematic models for assessment of glomerular filtration rate with electron-beam CT in pigs.
• Dietary reversal of experimental hypercholesterolemia improves endothelial dysfunction of epicardial arteries but not of small coronary vessels in pigs.
• Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress.
• Endothelial function and cerebrovascular disease: implications for diagnosis and treatment.
• Endothelin-a receptor blockade improves renal microvascular architecture and function in experimental hypercholesterolemia.
• Evaluation of porcine myocardial microvascular permeability and fractional vascular volume using 64-slice helical computed tomography (CT).
• Examine thy heart with all diligence: evaluation of cardiac function using fast computed tomography.
• Genetics and smoking behavior.
• How do marital status, work effort, and wage rates interact?
• Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13.
• In vivo veritas: thrombosis mechanisms in animal models.
• Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development.
• Management of ventricular tachycardia in the absence of structural heart disease.
• Mechanism of outflow tract tachycardia.
• Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina.
• Redox-sensitive myocardial remodeling and dysfunction in swine diet-induced experimental hypercholesterolemia.
• Rethinking primary prevention of atherosclerosis-related diseases.
• Role of renal cortical neovascularization in experimental hypercholesterolemia.
• Simvastatin prevents coronary microvascular remodeling in renovascular hypertensive pigs.
• The dynamic vasa vasorum.
• The effect of drug eluting stents on cardiovascular events in patients with intermediate lesions and borderline fractional flow reserve.
• Ubiquitin and ubiquitin-like proteins in protein regulation.