Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus.

Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus. Research Abstract Details 

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Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus. Abstract Text:

L Dazord,Y le Garrec,M Bonnier,L Toujas,

Kinetics of proliferation in vivo and the effect on murine tumors of the vaccinal strain Brucella abortus B19 and two derivatives, 19BA and B19R, were studied. Inocula of 5 x 10(6) organisms of each strain produced comparable infections peaking on day 8. Several protocols of Brucella treatment yielded favorable results in EL4 lymphoma and Lewis tumor. The treatment for EL4 lymphoma seemed optimal 8--14 days after infection with 5 x 10(6) -- 5 x 10(7) organisms. In comparison with BCG, Brucella grew faster in vivo and accumulated more in the spleen. The effects of BCG and Brucella were comparable on EL4 lymphoma, but BCG was less effective than Brucella on Lewis tumor. The results encourage trials using live Brucella vaccine as an antitumor agent in man.

Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus. Publishing Authors By Initials

L Dazord,Y le Garrec,M Bonnier,L Toujas,

For similar neoplasms: neoplasms, experimental research abstracts see: neoplasms: neoplasms, experimental research

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Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 75

Page Numbers: 92-9

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1980

Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus. Information

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LANGUAGE: eng

NlmUniqueID: 44671

Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus. Keywords Mesh Terms:

KEYWORDS: Neoplasms, Experimental

MESH TERMS: immunology

Chemical & Substance for Abstract: Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus. Information

Substance Name: Brucella Vaccine

Registry Number: 0

Grant and Affiliation Information for Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus.

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Country: GERMANY, WEST

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MEDLINETA: Recent Results Cancer Res

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