Increased pressure stimulates aberrant dendritic cell maturation.

Increased pressure stimulates aberrant dendritic cell maturation. Research Abstract Details 

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Increased pressure stimulates aberrant dendritic cell maturation. Abstract Text:

Patients with malignancy typically exhibit abnormal dendritic cell profiles. Interstitial tumor pressure is increased 20-50mmHg over that in normal tissue. We hypothesized that elevated pressure in the tumor microenvironment may influence dendritic cell (DC) phenotype and function. Monocyte-derived immature and mature DC isolated from healthy human donors were exposed to either ambient or 40 mmHg increased pressure at 37 degrees C for 12 hours, then assessed for expression of CD80, CD86, CD83, CD40, MHC-I and MHC-II. IL-12 production and phagocytosis of CFSE-labeled tumor lysate were assessed in parallel. Elevated pressure significantly increased expression of all co-stimulatory and MHC molecules on mature DC. Immature DC significantly increased expression of CD80, CD86, CD83 and MHC-II, but not MHC-I and CD40, versus ambient pressure controls. Pressure-treated immature DC phenotypically resembled mature DC controls, but produced low IL-12. Phenotypic maturation correlated with decreased phagocytic capacity. These results suggest increased extracellular pressure may cause aberrant DC maturation and impair tumor immunosurveillance.

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Increased pressure stimulates aberrant dendritic cell maturation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cellular & molecular biology letters

VOLUME: 13

Page Numbers: 260-70

Journal Abbreviation: Cell. Mol. Biol. Lett.

ISSN: 1425-8153

DAY: 10

MONTH: 04

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 9607427

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Grant and Affiliation Information for Increased pressure stimulates aberrant dendritic cell maturation.

AFFILIATION: Department of Surgery, John D. Dingell VA Medical Center and Wayne State University, 4646 John R. Street, Detroit, MI, 48201, USA.

Country: Poland

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MEDLINETA: Cell Mol Biol Lett

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