Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence.

Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Research Abstract Details 

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Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Abstract Text:

Dan Yang,Donald J McCrann,Hao Nguyen,Cynthia St Hilaire,Ronald A DePinho,Matthew R Jones,Katya Ravid,

We previously reported that the frequency of polyploid aortic vascular smooth muscle cells (VSMC) serves as a biomarker of aging. Cellular senescence of somatic cells is another marker of aging that is characterized by the inability to undergo cell division. Here, we examined whether polyploidy is associated with the development of cellular senescence in vivo. Analysis of aortic tissue preparations from young and old Brown Norway rats showed that expression of senescence markers such as p16(INK4a) and senescence-associated beta-galactosidase activity are detected primarily in the old tissues. VSMC from p16(INK4a) knockout and control mice display similar levels of polyploid cells. Intriguingly, senescence markers are expressed in most, but not all, polyploid VSMC. Moreover, the polyploid cells exhibit limited proliferative capacity in comparison to their diploid counterparts. This study is the first to demonstrate in vivo that polyploid VSMC adopt a senescent phenotype.

Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Publishing Authors By Initials

D Yang,DJ McCrann,H Nguyen,C St Hilaire,RA DePinho,MR Jones,K Ravid,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Aging cell

VOLUME: 6

Page Numbers: 257-60

Journal Abbreviation: Aging Cell

ISSN: 1474-9718

DAY: 7

MONTH: 02

YEAR: 2007

Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Information

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LANGUAGE: eng

NlmUniqueID: 101130839

Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: metabolism

Chemical & Substance for Abstract: Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Information

Substance Name: Biological Markers

Registry Number: 0

Grant and Affiliation Information for Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence.

AFFILIATION: Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.

Country: England

AGENCY: United States NIA

GRANT: AG022623

ACRONYM: AG

MEDLINETA: Aging Cell

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