Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP).

Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP). Research Abstract Details 

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Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP). Abstract Text:

Hitoshi Maeshima,Tohru Ohnuma,Yoshie Sakai,Nobuto Shibata,Hajime Baba,Hiroshi Ihara,Maiko Higashi,Taku Ohkubo,Eiko Nozawa,Sawako Abe,Aya Ichikawa,Yoshiyuki Nakano,Yushi Utsumi,Toshihito Suzuki,Heii Arai,Hitoshi Maeshima,Tohru Ohnuma,Yoshie Sakai,Nobuto Shibata,Hajime Baba,Hiroshi Ihara,Maiko Higashi,Taku Ohkubo,Eiko Nozawa,Sawako Abe,Aya Ichikawa,Yoshiyuki Nakano,Yushi Utsumi,Toshihito Suzuki,Heii Arai,

Disturbed glutamatergic neurotransmission has become recognized as a key component in the pathophysiology of schizophrenia. The change in serum/plasma glutamate with the use of antipsychotic medication has been studied and may be a possible clinical marker. In the present study, we examined plasma glutamate concentration, including a comprehensive investigation of its involvement with clinical course of schizophrenia and a genomic analysis. We performed a case-control genetic association analysis of the glutaminase 1 (GLS) and 2 (GLS2) genes. In addition, the difference in plasma glutamate concentration between the "acute stage" and "remission stage", and the effect of genotypes of SNPs within the two genes were assessed. The genetic association analysis of the GLS and GLS2 genes showed no association with schizophrenia. Plasma glutamate was increased with antipsychotic medication at "remission stage". Although GLS and GLS2 are not likely genetic risk factors for schizophrenia, changes in plasma glutamate concentration might be connected with clinical course of schizophrenia.

Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP). Publishing Authors By Initials

H Maeshima,T Ohnuma,Y Sakai,N Shibata,H Baba,H Ihara,M Higashi,T Ohkubo,E Nozawa,S Abe,A Ichikawa,Y Nakano,Y Utsumi,T Suzuki,H Arai,H Maeshima,T Ohnuma,Y Sakai,N Shibata,H Baba,H Ihara,M Higashi,T Ohkubo,E Nozawa,S Abe,A Ichikawa,Y Nakano,Y Utsumi,T Suzuki,H Arai,

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Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Progress in neuro-psychopharmacology & biological

VOLUME: 31

Page Numbers: 1410-8

Journal Abbreviation: Prog. Neuropsychopharmacol. Bi

ISSN: 0278-5846

DAY: 22

MONTH: 06

YEAR: 2007

Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP). Information

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LANGUAGE: eng

NlmUniqueID: 8211617

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Grant and Affiliation Information for Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP).

AFFILIATION: Department of Psychiatry, Juntendo University, School of Medicine, Tokyo, Japan.

Country: England

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MEDLINETA: Prog Neuropsychopharmacol Biol

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