Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice.

Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Research Abstract Details 

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Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Abstract Text:

Zhifeng Qi,Xiangning Bu,Ping Huang,Nan Zhang,Song Han,Li Fang,Junfa Li,

Our previous studies have demonstrated that hypoxic precondition (HPC) increased membrane translocation of protein kinase C isoforms and decreased phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) in the brain of mice. The goal of this study was to determine the involvement of p90 KD ribosomal S6 kinase (RSK) in cerebral HPC of mice. Using Western-blot analysis, we found that the levels of membrane/nuclear translocation, but not protein expression of RSK increased significantly in the frontal cortex and hippocampus of HPC mice. In addition, we found that the phosphorylation levels of RSK at the Ser227 site (a PDK1 phosphorylation site), but not at the Thr359/Ser363 sites (ERK1/2 phosphorylated sites) increased significantly in the brain of HPC mice. Similar results were confirmed by an immunostaining study of total RSK and phospho-Ser227 RSK. To further define the cellular populations to express phospho-Ser227 RSK, we found that the expression of phospho-Ser227 RSK co-localized with neurogranin, a neuron-specific marker, in cortex and hippocampus of HPC mice by using double-labeled immunofluorescent staining method. These results suggest that increased RSK membrane/nuclear translocation and PDK1 mediated neuron-specific phosphorylation of RSK at Ser227 might be involved in the development of cerebral HPC of mice.

Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Publishing Authors By Initials

Z Qi,X Bu,P Huang,N Zhang,S Han,L Fang,J Li,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: ribosomal protein s6 kinases: ribosomal protein s6 kinases, 90-kda research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: ribosomal protein s6 kinases: ribosomal protein s6 kinases, 90-kda research

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Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurochemical research

VOLUME: 32

Page Numbers: 1450-9

Journal Abbreviation: Neurochem. Res.

ISSN: 0364-3190

DAY: 3

MONTH: 04

YEAR: 2007

Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Information

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LANGUAGE: eng

NlmUniqueID: 7613461

Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Keywords Mesh Terms:

KEYWORDS: Ribosomal Protein S6 Kinases, 90-kDa

MESH TERMS: metabolism

Chemical & Substance for Abstract: Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Information

Substance Name: Ribosomal Protein S6 Kinases, 90-kDa

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice.

AFFILIATION: Department of Neurobiology, Beijing Key Laboratory for Neural Regeneration and Repairing, Institute for Biomedical Science of Pain, Capital Medical University, #10 You An Men Wai Xi Tou Tiao, Beijing 100069, Peoples' Republic of China.

Country: United States

AGENCY: United States NIDCR

GRANT: DE 15814

ACRONYM: DE

MEDLINETA: Neurochem Res

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