Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus.

Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. Abstract Text:

Vasileios C Kyttaris,Ying Wang,Yuang-Taung Juang,Arthur Weinstein,George C Tsokos,

T cells from patients with systemic lupus erythematosus (SLE) are characterized by heightened TCR-initiated free intracytoplasmic calcium responses. We demonstrate that activated T cells from SLE patients, but not from rheumatoid arthritis patients, displayed higher levels of the calcineurin-dependent transcription factor NF-ATc2 in the nucleus compared with control T cells. DNA NF-AT-binding activity was also increased, as was the amount of NF-ATc2 bound to the promoters of CD154 (CD40L) and IL-2 genes. Nevertheless, although high NF-ATc2 levels translated into higher CD154 transcription in SLE, IL-2 transcription was decreased. The absence of important transcriptional activators (AP-1, NF-kappaBeta) and the presence of transcriptional repressors (cAMP response element modulator) on the IL-2 promoter explain this dichotomous effect.

Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. Publishing Authors By Initials

VC Kyttaris,Y Wang,YT Juang,A Weinstein,GC Tsokos,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

PUBMED ID PMID:

MEDLINE DATE:

Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 178

Page Numbers: 1960-6

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Feb

YEAR: 2007

Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: immunology

Chemical & Substance for Abstract: Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. Information

Substance Name: CD40 Ligand

Registry Number: 147205-72-9

Grant and Affiliation Information for Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus.

AFFILIATION: Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI49954

ACRONYM: AI

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus Related Publications

• Altered signal transduction in SLE T cells.
• C3d-defined complement receptor-binding peptide p28 conjugated to circumsporozoite protein provides protection against Plasmodium berghei.
• CAMP response element modulator a expression in patients with systemic lupus erythematosus.
• Calcium signaling in systemic lupus erythematosus lymphocytes and its therapeutic exploitation.
• Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation.
• Common variable immune deficiency (CVID) presenting as an autoimmune disease: role of memory B cells.
• Detection and localization of the hydrophobic surfactant proteins B and C in human tear fluid and the human lacrimal system.
• Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression.
• Fatal pyomyositis: a report of 8 autopsy cases.
• Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase.
• How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype.
• Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus.
• Novel molecular targets in the treatment of systemic lupus erythematosus.
• PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells.
• Pathology and immunology of lupus glomerulonephritis: can we bridge the two?
• Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus.
• Sarcoidosis and mechanisms of unexpected death.
• Stability and translation of TCR zeta mRNA are regulated by the adenosine-uridine-rich elements in splice-deleted 3' untranslated region of zeta-chain.
• Symmetrical "mirror-image" injuries and the "chessboard" pattern: useful markers of self-mutilation.
• Systemic lupus erythematosus: new molecular targets.
• The RNA-stabilizing Protein HuR Regulates the Expression of {zeta} Chain of the Human T Cell Receptor-associated CD3 Complex.
• The processing of skeletonized human remains found in Berlin, Germany.
• The transcriptional repressor cAMP response element modulator alpha interacts with histone deacetylase 1 to repress promoter activity.
• VE-cadherin and ACE: Markers for sepsis in post mortem examination?
• [Death on a sauna stove]
• [Fatal attacks of zoo animals on humans--a case report]
• [Iatrogenic trauma following resuscitation measures]
• [Retrospective analysis of 5,108 pediatric case files under traumatological and forensic aspects: a contribution to the differential diagnosis of physical child abuse vs. falls]
• [Suicidal and accidental carbon monoxide poisonings due to charcoal fires in closed spaces]
• [Suicidal burrowing behavior--a special kind of the "hide-and-die-syndrome"]