Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine.

Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine. Research Abstract Details 

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Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine. Abstract Text:

Noriko Okada,Suzuka Asai,Aya Hotta,Noriko Miura,Naohito Ohno,Imre Farkas,Lewis Hau,Hidechika Okada,Noriko Okada,Suzuka Asai,Aya Hotta,Noriko Miura,Naohito Ohno,Imre Farkas,Lewis Hau,Hidechika Okada,

Amino acids 37 to 53 (RAARISLGPRCIKAFTE) of C5a anaphylatoxin form an essential region for C5a function. To target this sequence, we generated a complementary peptide (ASGAPAPGPAGPLRPMF) designated PepA which has a potent inhibitory effect on C5a activity. By introducing an acetyl group at the N-terminal alanine of PepA, an acetylated form was generated which was designated AcPepA. The acetylation resulted in increased inhibition of C5a stimulation of neutrophils as determined by Ca influx. Furthermore, AcPepA partially inhibited the lethal shock induced in mice by intravenous administration of Candida albicans water-soluble mannoprotein-beta-glucan complex. In addition, local skin inflammation in rats caused by an anti-Crry monoclonal antibody was suppressed when AcPepA and the antibody were injected together, while PepA had little inhibitory capacity. The potent inhibitory capacity of AcPepA was also confirmed by a skin reaction of guinea pigs inoculated with recombinant human C5a together with AcPepA.

Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine. Publishing Authors By Initials

N Okada,S Asai,A Hotta,N Miura,N Ohno,I Farkas,L Hau,H Okada,N Okada,S Asai,A Hotta,N Miura,N Ohno,I Farkas,L Hau,H Okada,

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Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbiology and immunology

VOLUME: 51

Page Numbers: 439-43

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ISSN: 0385-5600

DAY: 20

MONTH: 04

YEAR: 2007

Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine. Information

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LANGUAGE: eng

NlmUniqueID: 7703966

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Grant and Affiliation Information for Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine.

AFFILIATION: Department of Biodefense Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Country: Japan

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MEDLINETA: Microbiol Immunol

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