Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats.

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats. Research Abstract Details 

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Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats. Abstract Text:

Esben S Buhl,Susanne Neschen,Shin Yonemitsu,Joerg Rossbacher,Dongyan Zhang,Katsutaro Morino,Allan Flyvbjerg,Pascale Perret,Varman Samuel,Jung Kim,Gary W Cline,Kitt Falk Petersen,Esben S Buhl,Susanne Neschen,Shin Yonemitsu,Joerg Rossbacher,Dongyan Zhang,Katsutaro Morino,Allan Flyvbjerg,Pascale Perret,Varman Samuel,Jung Kim,Gary W Cline,Kitt Falk Petersen,

Individuals born with a low birth weight (LBW) have an increased prevalence of type 2 diabetes, but the mechanisms responsible for this association are unknown. Given the important role of insulin resistance in the pathogenesis of type 2 diabetes, we examined insulin sensitivity in a rat model of LBW due to intrauterine fetal stress. During the last 7 days of gestation, rat dams were treated with dexamethasone and insulin sensitivity was assessed in the LBW offspring by a hyperinsulinemic euglycemic clamp. The LBW group had liver-specific insulin resistance associated with increased levels of PEPCK expression. These changes were associated with pituitary hyperplasia of the ACTH-secreting cells, increased morning plasma ACTH concentrations, elevated corticosterone secretion during restraint stress, and an approximately 70% increase in 24-h urine corticosterone excretion. These data support the hypothesis that prenatal stress can result in chronic hyperactivity of the hypothalamic-pituitary-adrenal axis, resulting in increased plasma corticosterone concentrations, upregulation of hepatic gluconeogenesis, and hepatic insulin resistance.

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats. Publishing Authors By Initials

ES Buhl,S Neschen,S Yonemitsu,J Rossbacher,D Zhang,K Morino,A Flyvbjerg,P Perret,V Samuel,J Kim,GW Cline,KF Petersen,ES Buhl,S Neschen,S Yonemitsu,J Rossbacher,D Zhang,K Morino,A Flyvbjerg,P Perret,V Samuel,J Kim,GW Cline,KF Petersen,

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Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Endocrinology and

VOLUME: 293

Page Numbers: E1451-8

Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

ISSN: 0193-1849

DAY: 25

MONTH: 09

YEAR: 2007

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats. Information

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LANGUAGE: eng

NlmUniqueID: 100901226

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Grant and Affiliation Information for Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats.

AFFILIATION: Department of Pharmacology, Faculty of Health Sciences, Medical Department M, University of Aarhus, Aarhus, Denmark.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK40936

ACRONYM: DK

MEDLINETA: Am J Physiol Endocrinol Metab

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