Increased fronto-temporal perfusion in bipolar disorder.

Increased fronto-temporal perfusion in bipolar disorder. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Increased fronto-temporal perfusion in bipolar disorder. Abstract Text:

OBJECTIVES: Previous imaging reports showed over-activation of fronto-limbic structures in bipolar patients, particularly in response to emotional stimuli. In this study, for the first time, we used perfusion weighted imaging (PWI) to analyze lobar cerebral blood volume (CBV) in bipolar disorder to further explore the vascular component to its pathophysiology. METHODS: Fourteen patients with DSM-IV bipolar disorder (mean age+/-SD=49.00+/-12.30 years; 6 males, 8 females) and 29 normal controls (mean age+/-SD=45.07+/-10.30 years; 13 males, 16 females) were studied. PWI images were obtained following intravenous injection of paramagnetic contrast agent (Gadolinium-DTPA), with a 1.5 T Siemens magnet using an echo-planar sequence. The contrast of enhancement (CE), was calculated pixel by pixel as the ratio of the maximum signal intensity drop during the passage of contrast agent (Sm) by the baseline pre-bolus signal intensity (So) (CE=Sm/So()100) for frontal, temporal, parietal, and occipital lobes, bilaterally, on two axial images. Higher CE values correspond to lower CBV and viceversa. RESULTS: Bipolar patients had significantly lower CE values in left frontal and temporal lobes (p=0.01 and p=0.03, respectively) and significantly inverse laterality index for frontal lobe (p=0.017) compared to normal controls. No significant correlations between CE measure and age or clinical variables were found (p>0.05). CONCLUSION: This study found increased left frontal and temporal CBV in bipolar disorder. Fronto-temporal hyper-perfusion may sustain over-activation of these structures during emotion modulation, which have been observed in patients with bipolar illness.

Increased fronto-temporal perfusion in bipolar disorder. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Increased fronto-temporal perfusion in bipolar disorder. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of affective disorders

VOLUME: 110

Page Numbers: 106-14

Journal Abbreviation:

ISSN: 0165-0327

DAY: 21

MONTH: 02

YEAR: 2008

Increased fronto-temporal perfusion in bipolar disorder. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7906073

Increased fronto-temporal perfusion in bipolar disorder. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Increased fronto-temporal perfusion in bipolar disorder. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Increased fronto-temporal perfusion in bipolar disorder.

AFFILIATION: Department of Medical and Morphological Researches, Section of Radiology, University of Udine, Udine, Italy; Verona-Udine Brain Imaging and Neuropsychology Program, Inter-University Center for Behavioural Neurosciences, University of Udine, Italy.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Affect Disord

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Increased fronto-temporal perfusion in bipolar disorder Related Publications

• A case of two different tumors in the heart of a dog.
• Acceptance test of a commercially available software for automatic image registration of computed tomography (CT), magnetic resonance imaging (MRI) and 99mTc-methoxyisobutylisonitrile (MIBI) single-photon emission computed tomography (SPECT) brain images.
• An embedded optical nanowire loop resonator refractometric sensor.
• Correlation between induction of DNA fragmentation in lung cells from rats and humans and carcinogenic activity.
• Cortical white-matter microstructure in schizophrenia. Diffusion imaging study.
• Decreased entorhinal cortex volumes in schizophrenia.
• GABAergic function in detoxified heroin addicts: relationship to anxiety disorders.
• Human amnion: cytology and cell culture.
• Increased fronto-temporal perfusion in bipolar disorder.
• Is there a neurobiological basis of insight in schizophrenia?
• Liquid chromatographic method for nicarbazin in broiler feeds and premixtures: development, validation, and interlaboratory study.
• Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis.
• Management and outcomes of hepatic cirrhosis: Findings from the RING study.
• Neuroendocrine correlates of depression in abstinent heroin-dependent subjects.
• Neurotransmitter-neuroendocrine responses to experimentally induced aggression in humans: influence of personality variable.
• Outcome after endografting in small and large abdominal aortic aneurysms: a metanalysis.
• Percutaneous treatment of a single saphenous vein graft with two different protection devices.
• Primary adrenocortical sarcomatoid carcinoma: case report and review of literature.
• Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression.
• Serotonin function in detoxified heroin abusers: prolactin and cortisol responses to fenfluramine challenge.
• Simultaneous determination of Zilpaterol and other beta agonists in calf eye by gas chromatography/tandem mass spectrometry.
• Social cognition, schizophrenia and brain imaging.
• Tissue plasminogen activator to prevent central venous access device infections: a systematic review of central venous access catheter thrombosis, infection and thromboprophylaxis.
• [Effects of high ergotamine doses on development of Galliera sarcoma.]
• [Latex risk prevention in San Paolo Hospital in Milan]
• [Not Available.]
• [Pathophysiology and prevention of contrast-induced acute renal.]
• [Sepsis, acute renal failure and multiple organ dysfunction syndrome.]
• [Stimulate creativity by discovering oneself and communicating with others. Stimulation as a therapeutic instrument]
• [The city and clerics]